Quest location and layout is randomized, but the player may encounter radroaches (with the occasional glowing radroach), raiders, deathclaws, radscorpions, and feral ghouls. The quest objective always has a glowing ghoul accompanied by at least four feral ghouls.
- Guardian of the Wastes: Deathclaws!
- Guardian of the Wastes: Mole Rats!
- Guardian of the Wastes: Radroaches!
- Guardian of the Wastes: Radscorpions!