Giant rats appear to be larger versions of normal pre-War rats, although they appear to have lost most of their fur, they have spotted skin like molerats, and have glowing turquoise eyes. Similar to their pre-war counterparts, they have very large incisors. Giants rats are often found in darker areas, such as Cerulean Robotics, the broc flower cave and Vault 11.
Giant rats will not attack on sight, but will stand defensively in the way bighorners do when an enemy is spotted. Only when the player character comes in proximity or attacks them will they become hostile. Certain rats, such as the ones found in Freeside, will not attack despite being assaulted. As with most mutated animals, giant rats will not attack if the Courier has the Animal Friend perk. Giant rats are also susceptible to, and count towards, the Animal Control perk. Occasionally, idle rats will make a sound similar to a howl.
Giant rats are light brown color, with glowing blue eyes and white hair down its back. The standard giant rat is equal in size to a mole rat. They are quite fast and attack in groups of three to seven.
These young rats look identical to fully grown giant rats, albeit smaller than the standard giant rat. They usually don't attack but instead run away. However, if pups are encountered with normal giant rats, they will accompany them in the assault.
Found in the broc flower cave and New Vegas sewers, rodents of unusual size are the largest of the mutated rats found in the Mojave Wasteland to date. They are identical to their giant cousins, save for their increased size and attack strength. They are aggressive and will attack on sight unless the player character has the Animal Friend perk. They can sometimes be found in Vault 11 if the Wild Wasteland perk is chosen.
Every three days, two children in Freeside will be seen chasing a non-hostile giant rat. If the Courier kills the rat, the children will say "Thanks, mister/lady" and perform an eating animation on the rat (like the Courier will perform if they have the Cannibal perk). The children will still "eat" the rat even if it was reduced to a pile of goo or ash. Sometimes, they may perform this animation several feet away from the rat. Eventually, the rat will respawn and the children will resume their never-ending chase. It is likely that these children are working for Genaro, as he mentions that he has his "little helpers" who gather food for him. The children have knives and baseball bats, but they will never be able to catch up with and attack the rat.
Giant rats are friendly if the Courier has the Animal Friend perk, but may be hostile to companions.
It is possible to pickpocket a giant rat, though doing so will result in Karma loss.
There is a unique dialogue option with Lady Jane in Freeside during the quest Debt Collector if the Courier has the Wild Wasteland trait. They can ask her about the "R.O.U.S" in the broc flower cave where her raided caravan lies.
In Fallout: New Vegas concept art, the giant rat was described as "smaller than a dog but bigger than a cat."
The rodents of unusual size are named in reference to William Goldman's novel and film The Princess Bride. In the film and novel, rodents of unusual size (or ROUS for short) attack the protagonists. Like Fallout's rats, ROUSs are extremely large and dangerous.