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Francis may refer to:
- Sister Francis, a member of the Children of the Cathedral in Fallout.
- Francis (Fallout 2), a Broken Hills super mutant in Fallout 2.
- Francis O'Dell, a dead member of the Railroad in Fallout 4.
- Francis Perry, a former detective found dead as a skeleton in Fallout 4.
- Francis (Nuclear Winter), a resident of Vault 51 and candidate for overseer, mentioned in the Fallout 76 add-on Nuclear Winter.
- Francis (Project V13), a Brotherhood of Steel Elder, mentioned in The Armageddon Rag, Vol. 3.
- Real-life person:
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