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Research into possible cures for the New Plague created the Forced Evolution Virus, which was further developed in an attempt to create a transmittable genetic-engineering virus -- in effect, infectious evolution.ZAX 1.2

The Forced Evolutionary Virus, or FEV, is an artificial virus created by West Tek's NBC Division. Its ability to force changes in both the genotype and phenotype made it one of the most important mutagens in the wasteland, harnessed by different organizations and individuals for their own purposes both before and after the Great War.

The strain responsible for creating regular super mutants is called FEV-II[1][2] and represents the pinnacle of pre-War research into the virus. A different, unfinished FEV strain is the source of the super mutants infesting the Capital Wasteland, intellectually inferior to their West Coast cousins. Other strains created the monsters of Appalachia and the distinct super mutants of the Commonwealth, as well as served as the basis for the Institute's third-generation synths.

The FEV exists in various forms across all of the Fallout games, mainly to serve the goals of the various antagonists. It was through the FEV that the Master made his race of super mutants and how the Enclave meant to purify the world of mutation.

Characteristics

Overview

The Forced Evolutionary Virus is a megavirus, transmissable through direct contact or injection.[3][4] It cannot infect individuals through airborne transmission from an already infected individual.[4] In most cases it is seen in the form of a green liquid contained within large vats,[5] but it can also be administered via an aerosol solution.[6] It has a strong structure, described as having a protein sheath reinforced by ionized hydrogen, allowing it to absorb neutrons without being radioactive, making it immune to radiation.[3]

The purpose of the virus is to correct its host’s DNA. The virus is pre-programmed with corrected DNA patterns, appropriate to the proper type of species. When the host comes in contact with the virus, the virus will copy and store the DNA patterns of the host which are then re-injected back into the host’s cells with the virus’ corrected DNA patterns in a typical viral infectious method. The virus is partially reliant on DNA from the host, which can make results unpredictable.[7][8]

If administered to an individual with significant genetic damage, through radiation for example, the infection process is not able to occur correctly, leading to the body to suffer massive overhauling, increasing to organ failure and then death.[8]

When administered to a genetically viable individual, the infection process will rewrite portions of the host’s DNA, causing accelerated mutation, usually leading to very complete DNA strands[2] and recursive growth due to the FEV's own patterns. This recursive growth leads to an increase in muscle and brain mass, but is often accompanied by disfigurement and damage to existing neural patterns within the brain, causing loss of memory.[8] Accounts in both New California and the Capital Wasteland have described the mutation process to be painful.[9][10]

Cell death is offset by augmented growth, extending lifespans indefinitely.[11] Cell repair via mitosis reportedly occurs at a rate 15% faster than that of normal humans.[2] The virus also makes its host immune to radiation and disease.[12][13] Prolongued exposure to the virus causes individuals to develop tolerances to its effects, preventing full mutation but still resulting in side effects such as skin tone changes to a predominantly gray color, as well as increased strength and stamina.[14] A key drawback is that the virus renders the host sterile. It is theorised that the virus identifies gametes within the reproductive system to be damaged, due to them being “half-cells” and thus “repairs” them, preventing fertilization of pairing gametes.[11][2] There is no mention of the virus affecting the reproductive organs however.

FEV cannot be removed once infection has occurred, but the Institute scientist Dr. Brian Virgil created a serum to reverse the mutation, called a retrovirus.[15][16] Virgil stated that this serum would only work for one strain of FEV, and that generalizing the formula could take decades.[17][18]

FEV-II

Harry; a first generation super mutant exposed to the FEV-II strain.

The virus strain that has the most presence in the New California and Mojave Wasteland regions is FEV-II.[2][19] It has been administred to a variety of animal species, birthing the creation of creatures such as super mutants, centaurs and floaters. The first generation of these creatures were created by the Unity via the vats in the Mariposa Military Base,[20][Non-canon 1] while the second generation of predominatly super mutants were unintentionally created in the same area but years later during the Enclave excavations of the military base, following its destruction in 2161.[14]

In humans, physical and observational changes brought upon by the FEV-II strain are substantial. The best of the first generation super mutants were created from human subjects with a limited exposure to radiation or mutated FEV, such as those from Vaults within the region.[21] For the most stunning mutations to occur, a human subject would be left submerged within a vat of FEV-II for 24 hours, allowing them to receive a severe overdose of the virus from its exposure.[22][2]

A first generation super mutant autopsied by Vree had a height of 3.2 meters, and weighed 363.21 kilograms. Out of the total mass, 77.41% was accounted as muscle mass, with 10.23% of bone mass, 3.02% of fat mass and 9.34% of tissue mass.[2] The skin colour was described to be predominatly gray with tints of green under the lighting system of the Lost Hills bunker, while the skin's composition had reportedly become tougher, dry, and sometimes flaky, which would make it more resistant to trauma.[2][23] Despite this resistance to trauma, similarly to humans, completely destroyed tissue is unable to heal and will thus result in scarring or organ loss depending on the severity and location of the damage.[24]

Vree continuted to report that cells underwent cellular division at an increased rate, with mitosis occuring 15% faster than that of an average human. The mutant also had a highly similar cellular and genetic structure to the average human. All recessive genes for ailments appeared to have been eradicated from the mutant's body, with RNA strands appearing to have been manipulated to allow for a greater transmission of signals and bring out the best possible combination, but rendering the mutant sterile.[2]

The FEV-II strain has a small chance of increasing intelligence, with most retaining their intellect prior to their exposure.[Non-canon 2] Only a minority of remaining individuals may experience an increase, with the rest typically experiencing a loss by 30%.[Non-canon 2][2] However, those who have received a prolonged exposure to small amounts of the strain, such as the second generation super mutants, are noted to have a significantly worse intelligence than first generation super mutants, unable to think for themselves, often falling to the influence of others.[25][26]

EEP strain (FEV derivative)

Uncle Leo; a super mutant exposed to the EEP strain.

The modified, inferior FEV strain used at Vault 87 retains the recursive growth patterns characteristic to FEV, but has a different effect, which may be also linked to how infection was performed in the labs. Testing began in 2078,[27] where test subjects were exposed a single time to FEV in isolated chambers where the virus was deployed with an airborne aerosol. Phenotypical changes occur within three days and include increased muscle mass, changes in skeletal structure, and atrophy of sexual characteristics, both primary and secondary (including body hair). At ten days, skin pigmentation becomes a mixture of yellow and green, while its thickness and resistance to radiation and other environmental hazards rapidly increases.[27][28]

However, a key problem was that the mutation did not stop. Within fourteen days of initial exposure, test subjects regress to an almost feral state, exhibiting extreme aggression at every non-mutant. While some semblance of cognition is retained, exhibited by the ability to speak, operate machines and use basic tactics in combat, super mutants of this type are typically characterized by significant mental retardation.[28] This result is most likely brought upon by the same factor as with FEV-II: Damage to existing neural patterns caused by rapid changes in the phenotype. The effects typically cause significant damage to long term memory, again, a shared characteristic.[29] The traumatic nature of the transformation is also a factor. The excruciating pain that accompanies it can and will cause the subjects to become insane.[30][27]

Another unforeseen side effect is that the unfinished virus strain codes the body for continued growth. If a super mutant of this type eludes death for prolonged periods of time, they may become a considerable threat, reaching the size of a small building.[27]

Institute strains

Strong; a super mutant exposed to one of the Institute's FEV strains.

The super mutants of the Commonwealth are a completely different strain from others. While they possess the imposing musculature and resilience of the former, they have an average level of intelligence on par with examples of the latter. They are capable of following a chain of command, erecting fortifications,[31] and even setting up traps and ambushes - such as at Trinity Tower, where Fist deliberately used Rex Goodman as bait to lure humans and weed out the weak super mutants among his host. They are also capable of speaking like normal humans, unlike their practically feral brethren from the Capital Wasteland, and consider themselves the superior race of the Commonwealth.[32] All super mutants of the Commonwealth are products of the Institute's experiments into FEV using the abducted Commonwealth wastelanders above ground. These experiments were the base work used to progress their synths from mechanical construction to a new frontier using human DNA as a base to construct synthetic humans. The Super mutant (Fallout 4)s share a similar morphology with the super mutants derived from Appalachian West Tek's experiments on the Huntersville strain, but is unknown if the two strains are closely related.

Main article: Generation 3 synth

A third generation synth Courser.

The most advanced synthetics created by the Institute are fundamentally different from their predecessors. Despite the sequential numbering, they are unrelated to their mechanical counterparts, in fact. They are derived from Shaun's pre-War DNA extensively modified using the Institute's own research into the Forced Evolutionary Virus, combining the advantageous adaptations encoded into FEV with the versatility of the human body shape. This allowed the Institute to create a variety of synths of varying races and appearances despite the base DNA coming from only one source. They are the result of nearly five decades of research, from 2178 to 2227.[33][34][35][36]

Third generation synthetics are unlike humans and some liberated synths do not consider themselves human at all. The reasons for this are multiple, chief among them is the assembly process.[37] Other reasons include the fact that synths do not require sleep at all to function properly, are completely immune to disease, and do not require the intake of food or water to generate energy for their bodies.[38]

Huntersville strain

Grahm; a super mutant exposed to the Huntersville strain.

The Appalachia Super Mutants were created shortly before the Great War, when the local West Tek facility contaminated the river water that ran through Huntersville with a unique strain of FEV as part of an experiment.[39]

The super mutants of Huntersville are similar to those of Mariposa and the Institute: they have green skin, highly developed musculature, and they are smart enough to build improvised armor from waste or scrap. Although they do not use large fortifications like the Vault 87 or the Institute strain super mutants, they can occasionally build small fortresses or take entire buildings. The possess the same level of strength and durability and are intelligent enough to mount offenses against factions and other groups.[40] Like Vault 87 and Institute super mutants, Huntersville super mutants can develop into behemoths, which can be seen guarding their main bases. The majority of the super mutants will attack the player character, but some super mutants like Grahm are friendly and will even trade with humans.

Related projects

Appalachian experiments

Experiments with recombinant strains of FEV at the West Tek Research Center in Appalachia produced numerous failed mutations, with two exceptions:

  • FEVS-006443 from October 14, 2077, a Phase 2 combination strain that combined traits that resembled a number of different species. The results were considered disturbing by the scientists but provided valuable insights as to the capability of recombinant FEV. Notable changes included a number of ocular organs along the enlarged upper torso, the second set of arms ending in clawed digits, and a large sickle-shaped claw on each inner toe. The living, stable, and functioning subject was sustaining itself normally (a major accomplishment for the program) and was planned for release in Huntersville after the subsequent experiment matured.[41] The mutant was never returned to the area until January 3, 2078, when it escaped containment and the facility. The mutant procreated, leading to the emergence of snallygaster mutants across Appalachia.[42]
  • FEVS-006458 from October 23, 2077. Tweaking the snallygaster strain, researchers tweaked the genome, producing a giant that shattered the containment unit, but was otherwise stable (excepting the absence of a discernible head). The mutant was sedated and transported off-site, with the Great War sidetracking the convoy and allowing the Grafton monster to escape into the wild.[43]

Albino mole rats

Main article: Albino mole rat

Before the destruction of The Glow, lab rats were exposed to FEV. In the turmoil of the facility's destruction, they escaped into the wasteland. Similar to the Enclave's later experiments with deathclaws, these two unique rats gained intelligence and ability to talk, along with a long lifespan.[44]

Psyker program

Main article: Psyker

Apart from transforming humans into super mutants, the Master and his staff experimented with FEV by injecting it into the brains of the subjects (usually the pineal gland, but also the amygdala or medulla), triggering changes in brain chemistry.[45] These experiments had limited success: four extremely powerful psykers were created, capable of theoretically wiping out the human race.[Non-canon 3] However, the same changes that increased psychic ability also resulted in terminal insanity, forcing them to be sequestered and nullified to prevent them from harming themselves or others.[46]

FEV Curling-13 strain

Main article: FEV Curling-13

Based on the original FEV-II recovered by the Enclave at the Mariposa Military Base's ruins, FEV Curling-13 was a viral agent tailored to reach maximum levels of lethality with minimal exposure levels required to achieve the result. It was being developed under the direction of Lieutenant Colonel Dr. Charles Curling of the Chemical Corps since 2236, to provide the means for the Enclave's genocide. Just a .0001% aerosol solution exposure was enough to kill Arroyo villagers in under one hour, as massive hemorrhaging and inflammations start, leading to a complete failure of the victim's organs within sixty minutes. A significant radiation-induced mutation may thus be beneficial – humans with a lower radiation count suffer a much worse fate. Unmutated Vault 13 dwellers exposed to the virus experienced subdermal hemorrhaging and convulsions within sixty minutes of exposure, but their agony lasted much longer – 14.5 hours on average. No test subject survived the tests on Control Station Enclave.[6]

Interestingly, in the event of worldwide release, only humans and human-based mutants would be eradicated, however – FEV was engineered to bond only with human glycoproteins, leaving other animals and plant life alive and unaffected.[47] FEV Curling-13 is also unique in that it is the only known FEV strain for which an inoculation was developed that granted total immunity from its effects.[48]

Modified FEV Curling-13

Main article: Modified FEV

A modified strain of the Forced Evolutionary Virus developed by John Henry Eden, based on the earlier FEV Curling-13 strain used by the Enclave in 2241, only now it was designed to be placed into the Project Purity water purification system.[49] According to President Eden it will eradicate super mutants, ghouls, and all other "unclean" citizens, namely anyone who had been born in the Wastelands and exposed to radiation or other mutational effects from birth.[50] The only people who would survive the infection are dangerous radiation level free humans and humans who were born in the Vaults.[51]

In the add-on Broken Steel, if the Lone Wanderer had chosen to contaminate the purifier with the modified FEV, what President Eden claimed is confirmed to be accurate and the FEV diffused in water completely lethal. The medical facility of every city in the Capital Wasteland (except Tenpenny Tower and Paradise Falls) is filled with new patients dying from FEV infection. These new patients hold their stomachs and repeat dialogue along the lines of, "it burns on the inside." According to both Doctor Preston and Doctor Barrows, the FEV specifically targets the immune system of infected individuals, which in turn makes them vulnerable to other diseases. This occurs in both humans and ghouls, despite the latter's immunity to most diseases.[52][53] Along with affecting the immune system, the FEV severely weaken individuals both physically and mentally until it simply kills them.[54] The modified FEV is also completely undetectable by any kind of test meaning there is no possible way to screen water that has been infected as it only comes back as clean, purified water.[55]

The FEV is contained to only those that have ingested infected water as the transmission of FEV is impossible from physical contact or bodily fluids. In Rivet City, Dr. Preston comments that they are burning the corpses just to be safe.[52] The spread of FEV is contained to only bottles of Aqua Pura and the Tidal Basin for now. However, eventually, the spread of the FEV infected water will spread from the Tidal Basin and affect all water in the Capital Wasteland.

Intelligent deathclaws

Main article: Intelligent deathclaw

In 2235, the Enclave began experiments on captive deathclaws to create expendable shock troops for their use, continuing the pre-War project.[Non-canon 4] The recovery of FEV from Mariposa allowed them to create a tailored mutagen that increased the intelligence of deathclaws after localized injections, making them capable of understanding and following complex commands, as well as communication. The resulting modification overshot the project goals, giving them human-level intelligence, erudition, and most importantly, morality. Realizing that they would be exterminated if that was discovered, Gruthar instructed his pack to play dumb until they were deployed to Vault 13. Although the Enclave intended to use them as deterrence, the deathclaws formed a commune instead, deserting their mission. Not all deathclaws were equally blessed with intelligence and some experienced further changes, including a gray skin and a bobtail.[56]

All intelligent deathclaws were exterminated by a task force headed by Frank Horrigan, mopping the project up.[57]

Fire ants

Main article: Fire ant

Fire ant.png

FEV was synthesized and used by Weston Lesko in the Capital Wasteland around 2277, in an attempt to return giant ants to their normal size through genetic manipulation. His ambition was to reduce their size exponentially over the course of several generations. An error in the synthesis process created a virus that left the ants' size unaltered but altered their venom sacks to produce a flammable liquid that they can aerosolize, project, and ignite with a spark generated by clicking mandibles. The resulting pyrosis, as he calls it, turns them effectively into walking flamethrowers.[58][59][60]

History of the FEV

A long story. FEV... a virus with an even longer story...Father Elijah, Dead Money

The Forced Evolution Virus originated from the Pan-Immunity Virion Project, a project originally dedicated to discovering a cure for the New Plague, was established in September 2073 in response to aggressive use of biochemical weapons by China. In order to combat the newest biological weapons, the decision was made to create a viral defense that would alter uninfected DNA to render it immune to standard viral infection.[61] The last attempt to continue the PVP line of experimentation was the Greenhouse Initiative in August 2075 at the newly established Appalachian branch, which attempted to use mutations to create edible plants and vegetation that could greatly increase food production and combat the shortages that led to the food riots rocking the country.[62] The town of Huntersville was selected as the test site, resulting in an economic boom.[63] Although the company would purchase test rights from local farmers as late as December 2075, the project was at an end.[64]

Batch 10-011 and the beginning of FEV

The history of the FEV starts with Pan-Immunity Virion batch 10-011, renamed as the Forced Evolutionary Virus (FEV) and used in further research. The key difference was that instead of Pan-Immunity Virion's quad-helix DNA structure, the batch became a shifting-absorptive virus. This was a deliberate choice by Major Barnett, who considered the unwanted side effects of the quad-helix structure to outweigh the benefits of replicative stability afforded by the design.[65]

The first experiments took place in March 21, 2075 on single-celled organisms. While their base metabolism appeared unchanged, their immunity to infection and radiation exceeded all earlier expectations. Research on FEV effects on plants proved unsuccessful. The next stage included flatworms. Infected on May 9, 2075, they exhibited a 28% increase in size and resistance to 9 separate viral contagions within hours. The new DNA structure was successfully passed to progeny, though only asexual reproduction was possible.[65]

June 30, 2075, saw the next stage of experimentation: several lab strains of white mice have been infected successfully with FEV. Within hours they exhibited increased growth, stabilizing at a 31% size increase after nine days. The most increase in size occurred in striated muscle tissue and certain internal organs, including the liver, heart, and kidneys. An increase in intelligence was also noted, allowing mice to run mazes in less than half the time required by normal mice.[65]

The final experimentation with FEV batch 10-011 occurred with rabbits. On November 9, 2075, 218 rabbits were infected, half of which were implanted with electrodes to monitor changes in EEG activity. Increased electrical activity was noted 3.2 seconds after infection, accompanied by the typical increase in size. A new effect was noted, namely an increase in aggression and posturing, particularly among males. Dissection of the brains showed an increased dendritic connection, particularly in the limbic system and frontal cortex (areas responsible for behavior, senses and higher mental functions).[65]

Batch 11-011 and nationalization

On January 6, 2076, West Tek was effectively nationalized after military units deployed to corporate facilities across the United States in the interest of national security.[66] Experiments continued with Batch 11-011. The new virus batch featured improved mitotic cycle efficiency by a factor of 43%. As part of the test, 53 raccoons were infected with the new strain on January 26, 2076. Along with the expected size increase, behavioral tests confirmed an increase in intelligence and manual dexterity by 19 points on the Schuler-Kapp index. Unfortunately, subjects escaped confinement and had to be hunted down. Two pairs were unaccounted for.[65][Non-canon 5]

In February, the West Tek facility in Appalachia joined the FEV research effort, ordered to begin human experimentation in order to push FEV to its practical limits, in what was dubbed the Super Mutant program. Due to the virulent nature of the virus and its unpredictability, the facility's objective was to identify and isolate viable FEV strains through a variety of methods. The most important of these was the introduction of one of the FEV strains to the water supply of Huntersville, to observe the effects of long-term low-level exposure. The experiment began in February 2076, providing valuable research data for the project.[67]

Further development occurred after several new gene sequences, supplied by Major Barnett's advisory team, were spliced into FEV batch 11-011. Designated batch 11-101a, this batch was used to infect 23 dogs of pure and mixed breed on May 13, 2076. The results included nearly immediate growth, accompanied by increased aggression and no notable increase in intelligence. All subjects were terminated after 14 weeks of study. 92 allele pairs were chosen for splicing with batch 11-011.[65]

Batch 11-111 and further human research

The new hybrid batch was designated 11-111. On October 4, 2076, it was used to infect 15 chimpanzees. Growth and immunity levels were unprecedented: attempts to induce cancers through radiological and chemical agents were not successful. Increased aggression led to isolating the subjects by the science team, while violent epileptic seizures caused two subjects to expire. The rest was terminated after all data was mined successfully.[65] Despite protests from the science team, on January 7, 2077, FEV research in California was transferred to the Mariposa Military Base [65] to continue under the lead of Leon Von Felden and Robert Anderson. Batch 11-111 has been chosen as the basis for further development through human experimentation. The batch offered a near 100% success rate on lab animals, granting an approximately 60% increase in size and potential 200% intelligence increase. It was the perfect basis for mass-producing super soldiers.[61]

The Appalachian branch continued its experimentation by pushing FEV to its practical limits and experimenting with recombinant strains. The experimental strains resulted in the creation of many unsustainable forms: FEVS-005938 tested on January 13, 2077, rendered the subject unable to breathe,[68] FEVS-006186 from April 30 converted the subject into a mass of retinal tissue,[69] FEVS-006309 from July 12 produced canines that pierced the brain stem through unrestrained growth,[70] and FEVS-006378 from July 12 was biologically stable, but the hyperactive nervous system subjected it to constant traumatic pain and led to self-termination.[71] The team had more luck with strains FEVS-006443 (October 14) and FEVS-006458 (October 23) that created stable mutations that would become the snallygaster and the Grafton monster respectively after their escape into the wild.[41][43]

Another research effort was set up by the Vault-Tec Corporation in Washington, D.C. Vault 87 was established as an independent research center for Dr. Wayne Merrick, cooperating with the team at Mariposa. Despite his efforts, he was unable to improve batch 11-111 enough to reach satisfactory effects. Humans subject to his strains produced in the Vault 87 labs exhibited superior physical developments, such as increased size, strength, and endurance to environmental factors, but were also characterized by significant mental disability and extreme aggression to non-mutants.[28]

Compared to Merrick's efforts and Appalachian experiments, the science team at Mariposa reached a full success. They succeeded in creating the FEV-II strain, able to create powerful super-soldiers, exhibiting superior physical prowess, resistance to combat damage, aging, and disease, as well as a negligible loss of intelligence.[2] In certain cases, intelligence could even be increased by the virus. However, before the testing could begin in full, soldiers under the command of Roger Maxson rebelled and executed the science staff. With the Great War destroying the United States, Mariposa and research within was sealed by the soldiers and abandoned.[72]

Vault 87

Modified FEV was utilized as a part of the Vault 87 experiment. The scientists within the Vault noted their efforts toward the Evolutionary Experimentation Program, or EEP, at the behest of Vault-Tec and the military members at Mariposa.[73] Some strains caused fatalities, and causes of death were obscured from family members.[74]

Post-War

The Unity

The vats were rediscovered in 2102 by an expedition led by Harold, a major Hub merchant. Accompanied by Richard Grey, a brilliant exile from Vault City, he managed to crack the Mariposa base security and infiltrate the lower levels. However, within the vats, the automated crane crashed into the two, knocking Harold out and flinging Grey into the vat with FEV. Harold woke up in the wastes outside the base, mutating due to exposure to FEV fumes, but becoming a special type of a ghoul-like mutant, rather than a super mutant. Grey, on the other hand, underwent extreme mutation due to prolonged exposure to the virus in the vat. His intellect grew exponentially, allowing him to comprehend even the most complex issues easily (or so he thought).[Non-canon 6][75] Grey methodically researched FEV, experimenting with animals and eventually, captured scavengers that strayed into the facility. It was not until a few failed mutations that he discovered radiation count to be a deciding factor in the success of the change, leading him to pick subjects more carefully.[75][Non-canon 7] When his Lieutenant was created, he suggested a secondary reason for possible incompatibility. Reviewing available evidence, he concluded that failed mutations in relatively non-radiated humans are caused by the inoculating effect mutated FEV had on humans with which it came into contact.[76] Such exposure was not enough to cause phenotypical changes, but enough to cause conflicts when the pure FEV in Mariposa attempted to change the DNA, resulting in the death of the subject.[77]

By carefully selecting his test subjects, he managed to create the first real super mutants in January 2103.[Non-canon 8] Through a combination of willing converts and abductions, the Master slowly builds up the foundations for his army between 2103 and 2130.[Non-canon 9] The impact of the Great Winter of 2130 results in him stepping up his operations and spreading them out into the wasteland, attacking caravans to gather human stock for transformations. The string of attacks between 2131 and 2135 boosts the size of his army. The attacks are blamed on desert monsters in the Hub.[Non-canon 10] Due to reliance on wastelanders, only 20% of the dipped population survives the dipping and of that number, only half seem to last and become a part of the Unity. Regardless, it continues to grow.[Non-canon 11]

By 2152, the Unity's influence has spread through the wastes and the Master recruited a group of doomsday cultists under Morpheus to act as spies, rather than stock for transformation.[Non-canon 12] Four years later, the cultists would form the Children of the Cathedral to act as a front for the Unity, proselytizing, recruiting, and preparing munition dumps for the coming super mutant offensive.[Non-canon 13] Between 2155 and 2156, the Master makes another important discovery: His forces intercept a caravan of Vault dwellers, leading him to discover Vault-Tec's demonstration Vault. He moved his command center to the Vault, using the cultists to set up the Cathedral, and launched a campaign to discover Vaults to gain prime subjects for his super mutant army.[Non-canon 14] At least one installation, Vault 17, was discovered and its inhabitants transformed into super mutants. The success rate is far higher than when using regular wastelanders. Even the elderly Lily Bowen was successfully transformed into a super mutant at the age of 75 - and a nightkin no less![78]

The Master and his staff also experimented with FEV by injecting it into the brains of the subjects (usually the pineal gland, but also the amygdala or medulla), triggering changes in brain chemistry.[79] These experiments had limited success: four extremely powerful psykers were created, capable of theoretically wiping out the human race.[Non-canon 3]

By 2161, the Unity was on the verge of achieving total military superiority over the human inhabitants of New California. All that was needed was Vault 13 and its inhabitants.[80] Ironically, all FEV development and experimentation by the Master was abruptly halted by the Vault Dweller, of the very Vault the Master needed to dominate the New West.[81]

Vault 96

Edgar Blackburn began his own, independent research initiative into FEV, after realizing that observation, not a cure, was the purpose of the West Tek initiatives at Huntersville.[82] He was not sure what the purpose of infecting the water supply was, apart from this observation, as they knew the virus in its current state "produced horrors."[82][83] He resolved to make good on the promise of FEV and create a true immunizing agent that would cause humanity to evolve. Blackburn continued his work after the war in Vault 96, utilizing human subjects abducted by a group of mercenaries called the Hellcat Company in an attempt to create "perfected FEV."[84][85] Super mutants created were considered failures by Blackburn, and set free outside the Vault.[86]

Enclave FEV Curling-13

Seeking the means to achieve their plans of global genocide, the Enclave excavated Mariposa from July to August 2236, in search of surviving samples of FEV-II. Using slaves captured in towns across California, they managed to uncover the vats and secure the necessary scientific material. However, slaves exposed to the raw virus in the ruins of the base mutated, creating the second generation super mutants.[76] The uneven nature of exposure, coupled with a significant radiation count meant that those that survived the change suffered from significant mental damage. Retreating from the base, the Enclave blasted the only remaining entrance, trapping the mutants inside.[76]

Enclave's Chemical Corps proceeded to work on the acquired samples of the virus, creating a staggeringly effective killer, tailored to provide maximum lethality with minimal required exposure. However, two weeks before the virus' deployment, the Enclave, and the virus stockpiles were destroyed. However, copies of research were transmitted to Raven Rock, providing Raven Rock's ZAX John Henry Eden with an opportunity to achieve plans of genocide. After modifying the FEV Curling-13 to only target the heavily mutated and heavily irradiated, the ZAX unit decided a localized infection of the water supply would be more effective at culling the undesirables while also improving the quality of life for the unmutated and unirradiated.[87][88][89]

Enclave Modified FEV

The Enclave contingent in the Capital Wasteland utilized a modification of FEV at the behest of President John Henry Eden.[90] This modified FEV was created in an attempt to murder individuals living in the area by contaminating the water supply using the Project Purity facility.[91] President Eden states that the only people who would survive the infection are members of the Enclave and those who were born in the Vaults.[92][93]

The modified FEV specifically targets the immune system of infected individuals on a cellular level.[94][95] Barrows mentions that ghouls are usually immune to diseases, but are impacted alongside humans.[95] The modified FEV is undetectable in water that has been infected.[96]

The Institute

Commonwealth super mutants are the result of the Institute's research into FEV, which has continued since the early 2220s in a dedicated facility. The original goal was the creation of a successor to second generation synths by creating a new breed of super mutant that would serve the Institute as laborer and soldier. Due to a lack of success with mutants, efforts were refocused with the goal of creating third-generation synths. The organic synth project was spun off from the FEV research initiative around 2227 (the acquisition of Shaun), while the FEV research effort continued for several more decades.[34][35] Both women and men were abducted from the Commonwealth and submerged in the Institute's modified FEV, their mutations carefully tracked. Successful mutations would be monitored to ensured survivability, then tagged and discarded.[97] In layman's terms, the Institute was simply releasing super mutants into the wild, creating a scourge on the Commonwealth that lasted for years.[98] When Brian Virgil succeeded Dr. Syverson as head of the project in April 2286, it became evident that FEV experimentation ran its course and served no useful purpose, not with the availability of third generation synths.[36] Eventually, as Virgil's conscience took its toll, the scientist lodged a formal complaint with the Directorate.[34] When no reaction came, Virgil rebelled and escaped the Institute after transforming himself into a super mutant, destroying as much of the project as he could.[99] The wrecked Institute FEV lab was marked as a biohazard area and sealed off in the wake of his escape.[100][101] The whole incident was covered up, even from ranking Institute members, such as Madison Li, contributing to her dissatisfaction.[102]

Appearances

The Forced Evolutionary Virus appears in Fallout 2, Fallout 3, Fallout 4 and Fallout 76. It is also mentioned in Fallout: New Vegas.

Behind the scenes

[A] dip in FEV has a chance of modifying Intelligence, but it doesn't always increase it. Some people do gain increased intelligence, a larger majority lose intelligence and most people remain the same. It also depends if people have enough radiation damage to be turned into ghouls or super mutants.Chris Taylor, Fallout Bible 5

The Forced Evolutionary Virus is mentioned in the Fallout Bible.

Gallery

Videos

References

  1. The Vault Dweller: "{133}{}{I happen to know that your mutants are sterile.}"
    Master: "{135}{Mast11}{Preposterous! The FEV-2 virus doesn't destroy the reproductive organs of those it mutates.}"
    (MASTER.MSG)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Vree's autopsy report
  3. 3.0 3.1 Vault Dweller: "Why isn't FEV affected by radiation?"
    ZAX 1.2: "The FEV is a megavirus, with a protein sheath reinforced by ionized hydrogen. It is therefore capable of absorbing neutrons without becoming radioactive."
    (ZAX 1.2's dialogue)
  4. 4.0 4.1 Vault Dweller: "How do you catch FEV?"
    ZAX 1.2: "FEV is not 'caught', per se. It is not air-transmittable. Typically, infection is through injection, or direct physical contact with an FEV sample."
    (ZAX 1.2's dialogue)
  5. Mariposa Military Base#Structure
    West Tek research center (Fallout 76)#Layout
  6. 6.0 6.1 The Project
    Final tests conducted on the Vault-descendant subjects, from the village "Arroyo," have shown a survival rate of zero-percent, with most deaths occurring within one-hour of exposure to a .0001% aerosol solution.
  7. Vault Dweller: "How does the virus work?"
    ZAX 1.2: "My research into the Forced Evolution Virus, or FEV, indicates that it is a shifting-absorptive virus. It copies DNA patterns much like RNA, storing these patterns in exons. These exons, combined with the FEV, are re-injected into the host cells in typical viral infectious fashion. This causes the host cells to 'regenerate' their DNA."
    (ZAX 1.2's dialogue)
  8. 8.0 8.1 8.2 Vault Dweller: "If the FEV re-infects the host with its assimilated viral patterns, how does it make a 'better specimen'?"
    ZAX 1.2: "The FEV is pre-programmed with introns of corrected DNA appropriate to the proper type of species. It therefore attempts to correct the DNA of the individual. However, as the FEV is partially reliant upon the DNA of the individual, and also includes portions of its own recursive code, the effects can be unpredictable. When inoculated into an individual with significant genetic damage, such as through radiation, it will cause the body's systems to suffer massive overhauling, leading to organ failure and death. In a genetically viable individual, it re-writes portions of DNA, causing accelerated mutation, usually leading to recursive growth due to the FEV's own patterns. This recursive growth leads to an increase in muscle and brain mass, but is often accompanied by disfigurement and damage to existing neural patterns, causing loss of memory."
    (ZAX 1.2's dialogue)
  9. Richard Grey's audio diary; 0000 - 0004, 0021 - 0027, 0028 - 0043, 0044 - 0057
  10. Lone Wanderer: "So, tell me more about yourself."
    Fawkes: "I was born here, in this place. I don't mean that in the literal sense of course. All I can remember is the excruciating pain that tore through me as my body underwent the rapid physical changes. For most, this moment is what severs the grip on their minds. They become barely a shell of their former selves. I was different. When I spoke to them, they immediately branded me "another failure" and had me placed here as a curiosity."
    (Fawkes' dialogue)
  11. 11.0 11.1 Vault Dweller: "What potential long-term side effects exist?"
    ZAX 1.2: "As the FEV causes constant regenerative update to DNA, it would effectively render the subject largely immortal, as cell death would be offset by augmented growth. Additionally, as the gametes of the reproductive system consist of 'half-cells' using split DNA, they could be perceived as 'damage' by FEV, which would 'repair' them, rendering the subject sterile. However, as my laboratory facilities are damaged beyond repair, this is conjectural. I cannot offer physical proof. You will have to, in human terms, 'take my word for it."
    (ZAX 1.2's dialogue)
  12. Master: "Radiation has no effect on us. The FEV virus makes us immune. Your argument is weak, and so are you."
    (Master's dialogue)
  13. Vault Dweller: "How are you more advanced?"
    Lieutenant: "Intuitively obvious to the most casual observer. We are highly intelligent and immune to disease. The strong survive! It is our goal to improve the human race."
    (Lieutenant's dialogue)
  14. 14.0 14.1 Military base level 4
  15. Sole Survivor: "It'll work. Don't worry."
    Brian Virgil: "I hope so. We just have to let the retrovirus run its course. I'm going to rest for a while. Come back in a few days, maybe a week, and... well, I guess we'll see."
    (Brian Virgil's dialogue)
  16. Brian Virgil: "Retrovirus has matured nicely. Density gradient is high... Recombinant counter-intron sequences look stable... Transcriptive exon strands have formed..."
    (Brian Virgil's dialogue)
  17. Brian Virgil: "Welcome back. It needs some refinement, but I think we can consider my serum a qualified success."
    Sole Survivor: "This is a "qualified success"?"
    Brian Virgil: "There were some side effects to the process. I seem to have hair again. And I've retained some muscle mass. The genetic resequencer needs more work. Still, I take your point. This is a significant advance. But only for one strain of FEV. It will take years, perhaps decades, to generalize my formula."
    (Brian Virgil's dialogue)
  18. Vault Dweller: "Could FEV mutation be corrected with a counter-virus?"
    ZAX 1.2: "No. FEV does not retain unaltered original copies of the subject's DNA. Only a virus which re-infected the subject with original DNA could reverse the effects. Additionally, there is no known way to remove the FEV itself."
    (ZAX 1.2's dialogue)
  19. Vault Dweller: "{133}{}{I happen to know that your mutants are sterile.}"
    Master: "{135}{Mast11}{Preposterous! The FEV-2 virus doesn't destroy the reproductive organs of those it mutates.}"
    (Master's dialogue)
  20. Richard Grey's audio diary; 0173 - 0198, 0199 - 0236
  21. Lieutenant: {194}{LIEUT30}{The FEV was mutated by the war radiation. Those living in this desolate wasteland have been exposed to this mutant FEV, essentially inoculating them from the full effects.}
    Vault Dweller: "{195}{}{So?}"
    Lieutenant: {197}{LIEUT31}{So, you're from a Vault and have limited exposure to this mutated virus. The original FEV in the Vats should work quite well on you.}
    (Lieutenant's dialogue)
  22. Vault Dweller: "{142}{}{What is the current status of the patients?}"
    Vats control computer: "{143}{}{Current status on patients as follows: FEV batch #23872-A consists of four male units and two female units. All individuals suffering from FEV exposure. Vital signs are within normal parameters. FEV process on all subjects is approxiamtely 50% complete. Expect full FEV transformation within 12 hours.}"
    (Vats control computer dialogue)
  23. Doctor Troy: "{361}{}{My, your mutant friend had a great deal of bullets and shrapnel lodged in his body. It's a wonder he didn't have lead poisoning. I finally managed to get it all out. Here it all is.}"
    (Troy's dialogue)
  24. The cybernetic implants, branding scars, and the amputated tongue of the Lieutenant, Dog and God, and Mean Sonofabitch respectfully are examples of permanent tissue damage.
  25. Black Mountain Radio; Know Your Mutants; segment three
  26. The Courier: "How did Tabitha end up in control?"
    Neil: "The community ended up being mostly second gen - not very bright, but easy to influence. Fine, until the Nightkin came along, led by Tabitha..."
    (Neil's dialogue)
  27. 27.0 27.1 27.2 27.3 Fallout 3 Official Game Guide Game of the Year Edition p.42: "Super Mutants"
    "The Super Mutants that infest the urban ruin of Washington D.C. originated in Vault 87. Those unlucky enough to have reserved space in Vault 87 soon found themselves forcefully taken to a secure part of the Vault, where they were locked in airtight chambers and exposed to a concentrated form of the F.E.V. The Overseer and his security force had no real idea what to expect; they were simply following the "plan." When the exposed Vault dwellers started transforming into Super Mutants, nearly the entire Vault population had been exposed. Those who hadn't yet metamorphosed knew what was coming, and, well...it didn't end well for humanity.
    The dwellers of Vault 87 were turned into Super Mutants in 2078, and have been a presence in the Capital Wasteland ever since. Most of those original Super Mutants have long since been killed. But whether it's because of the nature of the F.E.V. they were exposed to, or a simple underlying human instinct, the Super Mutants of the Capital Wasteland are obsessed with the preservation of their own species. Super Mutants are asexual and incapable of procreation, so their only way of reproducing is to kidnap other humans, drag them back to the Vault 87 chambers, and infect them with F.E.V. And so they have done, for nearly 200 years.
    Super Mutant society is loosely hierarchical, with the weaker (most recently transformed) Super Mutants generally giving way to the stronger. The Super Mutant hierarchy, as defined by the Capital Wasteland contingent of the Brotherhood of Steel, is as follows: Grunt, Brute, Master, and Behemoth. Generally speaking, the Super Mutants of the Capital Wasteland get bigger, stronger, and dumber as they age. The Behemoths are so strong and savage that they’re the only thing feared by the other Super Mutants."
    (Fallout 3 Official Game Guide faction profiles)
  28. 28.0 28.1 28.2 Vault 87 terminal entries; Chief Physician's Terminal
  29. The Lone Wanderer: "Do you remember who you were?"
    Fawkes: "I don't remember enough to tell you everything about my former self. My metamorphosis destroyed a good deal of my long term memory. However, I can recall being in this place when it wasn't the macabre laboratory that it's become. I remember walking around this place and seeing other humans in white lab coats and blue jumpsuits. I wish I could find out more, but the personnel information for the Vault wasn't in the mainframe for some reason. I feel like my identity is so close to me... I can almost see myself as a human but can't recollect the details. It's maddening."
    (Fawkes' dialogue)
  30. The Lone Wanderer: "So, tell me more about yourself."
    Fawkes: "I was born here, in this place. I don't mean that in the literal sense of course. All I can remember is the excruciating pain that tore through me as my body underwent the rapid physical changes. For most, this moment is what severs the grip on their minds. They become barely a shell of their former selves. I was different. When I spoke to them, they immediately branded me "another failure" and had me placed here as a curiosity."
    (Fawkes' dialogue)
  31. The Prydwen terminal entries; Scribe Neriah's Terminal, Entry 0769-CM22
  32. Fallout 4 loading screens: "Super Mutants are stronger and more resilient than humans, and consider themselves the Commonwealth's superior race."
  33. The Sole Survivor: "Human synths? Really?"
    Shaun: "Human-like synths. A great distinction. The Institute endeavored to create synthetic organics. The most logical starting point, of course, was human DNA. Plenty of that was available, of course, but it had all become corrupted. In this... wasteland... radiation affected everyone. Even in their attempts to shield themselves from the world above, members of the Institute had been exposed. Another source was necessary. But then the Institute found me, after discovering records from Vault 111. An infant, frozen in time, protected from the radiation-induced mutations that had crept into every other human cell in the Commonwealth. I was exactly what they needed. And so it was my DNA that became the basis of the synthetic organics used to create every human-like synth you see today. I am their Father. Through Science, we are family. The synths, me... and you."
    (Shaun's dialogue)
  34. 34.0 34.1 34.2 The Institute terminal entries; Terminal, 2287.2.10: "Entered By: Virgil.B
    Notes:
    Nothing new. Always the same. Have entered formal complaint with Directorate; these tests are not bringing in any valuable information. The organics project was spun off decades ago. Why do we insist on continuing this?"
  35. 35.0 35.1 The Institute terminal entries; Terminal, 2277.7.10: "Entered By: Syverson.C
    Notes:
    Latest round of testing complete. Results are all within expected parameters. Informed Dr. Zimmer directly, as he had ordered the tests personally. He seemed annoyed with the results; unsure what he was looking for. He declined to specify why he wanted the tests run to begin with."
  36. 36.0 36.1 The Institute terminal entries; Terminal, 2286.4.10: "Entered by: Virgil.B
    Notes:
    I have officially assumed the lead role on the project after Dr. Syverson's passing.
    Latest round of subjects show results similar to previous test runs over last 5 years. No statistical deviation noted."
    Synthetic organics continue to perform well; the necessity of further tests is unexplained."
  37. The Sole Survivor: "How do they make synths?"
    Glory: "Damned if I know. The machines are... massive. Complicated. Not like anything I've seen out here. No matter what Dez and others say, synths ain't human. We're assembled bone by bone. Muscle by muscle. I've seen it. I'm gonna hit the range. I need to shoot something. Now."
    (Glory's dialogue)
  38. The Sole Survivor: "What makes them superior?"
    Max Loken: "The list of improvements is exhaustive. I can talk for an hour and still not cover all of it. Imagine what you could accomplish if you could live without fear of hunger or disease. Imagine what you could create if you could use every waking moment of your life as you saw fit, with no need of sleep? Like I said, a momentous time."
    (Max Loken's dialogue)
  39. Fallout 76 loading screens: "The first Super Mutants in Appalachia were created right before the Great War, when West Tek poisoned the drinking water of Huntersville with the FEV Virus, in a sinister, secret experiment gone horribly wrong."
  40. Battle of Huntersville and Assault of Fort Atlas
  41. 41.0 41.1 West Tek research center terminals; Advanced mutations lab terminal, Report: Test Subject AM52
  42. West Tek research center terminal entries; Advanced mutations lab terminal, SPECIAL REPORT: CONTAINMENT BREACH
  43. 43.0 43.1 West Tek research center terminals; Advanced mutations lab terminal, Report: Test Subject AM53
  44. The Brain: " {150}{}{Are you ready to become one of us?}"
    The Chosen One: "{152}{}{You mean become a giant rat?}"
    Brain: "{360}{}{You humans have such limited tolerances. I would have remained a normal rat if you humans hadn’t done your best to destroy the world. If it weren’t for the radiation, I wouldn’t be what I am today.}"
    The Chosen One: "{361}{}{And what’s that, exactly?}"
    Brain: "{380}{}{I was just one of many normal rats in a advanced research lab. Then, one day, there were explosions. Our cages were broken open, and we were doused with some sort of fluid from a huge vat.}"
    The Chosen One: "{381}{}{Then what?}"
    Brain: "{390}{}{I crawled outside. As I began to heal, I noticed that I had changed. I tried to communicate with people, but they all just tried to kill me. Humans are just too violent to survive under their own leadership -- but that's another story. The first step is to repair the reactor.}"
    (Brain (mole rat)'s dialogue)
  45. Mad scientist
  46. Mad scientist: "The Master's truth is revealed, resulting in increased psychic ability]]. [shakes his head] But the poor souls become terminally insane and must be sequestered and nullified to keep them from harming themselves or others."
    (MADSCI.MSG)
  47. The Chosen One: "{209}{}{I still don't understand how that's *perfect.*}"
    Charles Curling: "{211}{}{The F.E.V. toxin will only attack to humans, leaving everything else alive, better still, within a month all the mutants will be dead and the F.E.V. toxin will die out as soon as it runs out of hosts. }"
    (QCCURLNG.MSG)
  48. The Chosen One: "{237}{}{What about my people? Or me? Or you, for that matter?}"
    Charles Curling: "{238}{}{I can release the antidote into the air-system for all the cells. The detention level is served by a separate air system from the rest of the Enclave. Everyone will think that I'm just running another test. You, I can inoculate directly, here and now. (he reaches for you with a syringe)}"
    (QCCURLNG.MSG)
  49. The Lone Wanderer: "Where did this plan of yours come from?"
    John Henry Eden: "A great many years ago, the remnants of the government had a similar idea. I can only assume the plan failed, as I never heard word of its success. But the plan itself was sound. I've made a few modifications, and with your help, I do believe it can work. There's a bright future ahead of us, my young friend."
    (John Henry Eden's dialogue)
  50. The Lone Wanderer: "Say whatever it is you have to say."
    John Henry Eden: "Our land is ravaged by mutation. The war was so many years ago, and yet we still suffer from its effects. We cannot move forward until humanity can gain a solid foothold in the world. To do so, we must rid ourselves of the mutations that have plagued us for so long. These "Super Mutants", Ghouls, hideous creatures... I believe your father's work can do that in a way unlike any other."
    (John Henry Eden's dialogue)
  51. The Lone Wanderer: "Won't this kill pretty much everyone in the Wasteland?"
    John Henry Eden: "Anyone or anything that has been affected by mutation will be eliminated. You will likely be immune, thanks to your upbringing in the Vault. Likewise, the good people of the Enclave will be unaffected as well. I understand that you may have become sympathetic to certain individuals in your travels. Individuals this will eliminate. Please recognize that the fate of our entire country rests on this plan. Sacrifices must be made for the greater good."
    (John Henry Eden's dialogue)
  52. 52.0 52.1 The Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Doctor Preston: "Oh no... I'm fairly certain it's not contagious. Though, we are burning the bodies of the deceased, just in case... I just wish I knew how to treat these people. It's like their immune system is killing them. I don't know what to do about it!"
    (Doctor Preston's dialogue)
  53. The Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Doctor Barrows: "I don't know yet. Some kind of virus that attacks the body on a cellular level. I've never seen anything like it. It's strange because ghouls are immune to almost any known disease."
    (Doctor Barrows' dialogue in Broken Steel)
  54. If the Lone Wanderer drinks four bottles of Aqua Pura infected with the modified FEV, they suffer increasingly negative effects (that are temporary) such as loss of strength and intelligence until the last bottle that kills them.
  55. The Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Doctor Church: "There's something going around, all right, but it isn't anything I've ever seen before. Definitely not contagious. Maybe something in the water, but that seems unlikely since I've tested it and this is the cleanest water we've ever had. I have no idea how to help these people and it's really taken the shine off my normally sunny disposition."
    (Doc Church's dialogue)
  56. Intelligent deathclaws in Fallout 2.
  57. Canon Fallout 2 endings
  58. The Lone Wanderer: "So, what's gone wrong?"
    Weston Lesko: "Well. I'm afraid I've made slight miscalculations in the mutagen. Instead of lowering their size, the brood hatched with a new biomechanism. I call their genetic abberation pyrosis; the ability to emit flame from their bodies. I may be able to correct this error, but I can't get near my equipment."
    (Weston Lesko's dialogue)
  59. Marigold station terminal entries; Doctor Lesko's Terminal
  60. Grayditch terminal entries; Doctor Lesko's terminal
  61. 61.0 61.1 FEV research
  62. West Tek research center terminals; Greenhouse control terminal, Greenhouse Initiative
  63. Huntersville terminals; Gail Meyer's terminal, Personal Journal 08.20.75
  64. Huntersville terminals; Gail Meyer's terminal, Personal Journal 12.20.75
  65. 65.0 65.1 65.2 65.3 65.4 65.5 65.6 65.7 FEV experiment disk
  66. GPWRTERM.MSG
  67. West Tek research center terminals; Analysis terminal, FTS-3A Water Analysis
  68. West Tek research center terminal entries; Advanced mutations lab terminal, Report: Test Subject AM48
  69. West Tek research center terminal entries; Advanced mutations lab terminal, Report: Test Subject AM49
  70. West Tek research center terminal entries; Advanced mutations lab terminal, Report: Test Subject AM50
  71. West Tek research center terminal entries; Advanced mutations lab terminal, Report: Test Subject AM51
  72. History of the Brotherhood of Steel
  73. Vault 87 terminal entries; Chief physician's terminal, Entry 87-34190
  74. Vault 87 terminal entries; Engineering section, Service Issue Entry V87-007
  75. 75.0 75.1 Richard Grey's audio diary
  76. 76.0 76.1 76.2 Military base level 4
  77. The Vault Dweller: "{1001}{}{FEV}"
    Lieutenant: "{1104}{LIEUT60}{The Vats are where the FEV is stored, and where you normals become one of us. Of course, some die horrible, excruciatingly painful deaths, but well, those are the breaks.}"
    (LT.MSG)
  78. The Courier: "Where did you come from?"
    Lily Bowen: "I grew up in Vault 17. I never even saw the sun until I was 75 years old - that was when Super mutants raided the Vault and carried a lot of us off. Yes, Leo, I'm getting to that part! They made me one of them, and they put me to work in an army that was going to conquer California."
    (Lily Bowen's dialogue)
  79. Mad scientist: "{101}{}{Good evening, brother. What brings you to our little corner of heaven?}"
    The Vault Dweller: "{103}{}{I'm here to check on your progress.}"
    Mad scientist: "{112}{}{It's not going well. I've been injecting the FEV directly into the pineal gland, but I'm not getting the results I'd hoped for.}"
    The Vault Dweller: "{113}{}{Why don't you try injecting it directly into the Amygdala?}"
    The Vault Dweller: "{114}{}{Why don't you try injecting it into the Medula?}"
    (MADSCI.MSG)
  80. The Master
  81. Fallout events.
  82. 82.0 82.1 Huntersville memories
  83. FEV research log #5
  84. FEV research logs; FEV research log #112
  85. FEV research logs; FEV research log #148
  86. FEV research logs; FEV research log #57
  87. The Lone Wanderer: "My father's work? How is that relevant?"
    John Henry Eden: "The purifier your father helped create has the ability to provide clean water to the whole of this "Capital Wasteland". With a simple modification, it can be used to distribute agents that destroy mutated creatures upon ingestion. In time, we could eliminate all mutations in the Wasteland at the same time the good people of the world regain their health. I need you to make the modification necessary for this to succeed."
    (John Henry Eden's dialogue)
  88. The Lone Wanderer: "I'll do whatever I have to if it means getting rid of mutants."
    John Henry Eden: "I was hoping you would see it my way. If the water purifier can be activated, it can be used to distribute toxins that will eliminate any mutated creatures upon ingestion. The longer it runs, the cleaner the world becomes. I need you to see that it starts running, and that the necessary modification is made."
    (John Henry Eden's dialogue)
  89. Take it Back!
  90. Lone Wanderer: "Where did this plan of yours come from?"
    John Henry Eden: "A great many years ago, the remnants of the government had a similar idea. I can only assume the plan failed, as I never heard word of its success. But the plan itself was sound. I've made a few modifications, and with your help, I do believe it can work. There's a bright future ahead of us, my young friend."
    (John Henry Eden's dialogue)
  91. Lone Wanderer: "My father's work? How is that relevant?"
    John Henry Eden: "The purifier your father helped create has the ability to provide clean water to the whole of this "Capital Wasteland". With a simple modification, it can be used to distribute agents that destroy mutated creatures upon ingestion. In time, we could eliminate all mutations in the Wasteland at the same time the good people of the world regain their health. I need you to make the modification necessary for this to succeed."
    (John Henry Eden's dialogue)
  92. Lone Wanderer: "Won't this kill pretty much everyone in the Wasteland?"
    John Henry Eden: "Anyone or anything that has been affected by mutation will be eliminated. You will likely be immune, thanks to your upbringing in the Vault. Likewise, the good people of the Enclave will be unaffected as well. I understand that you may have become sympathetic to certain individuals in your travels. Individuals this will eliminate. Please recognize that the fate of our entire country rests on this plan. Sacrifices must be made for the greater good."
    (John Henry Eden's dialogue)
  93. Lone Wanderer: "I'll do whatever I have to if it means getting rid of mutants."
    John Henry Eden: "I was hoping you would see it my way. If the water purifier can be activated, it can be used to distribute toxins that will eliminate any mutated creatures upon ingestion. The longer it runs, the cleaner the world becomes. I need you to see that it starts running, and that the necessary modification is made."
    (John Henry Eden's dialogue)
  94. Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Dr. Preston: "Oh no... I'm fairly certain it's not contagious. Though, we are burning the bodies of the deceased, just in case... I just wish I knew how to treat these people. It's like their immune system is killing them. I don't know what to do about it!"
    (Preston's dialogue)
  95. 95.0 95.1 Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Dr. Barrows: "I don't know yet. Some kind of virus that attacks the body on a cellular level. I've never seen anything like it. It's strange because ghouls are immune to almost any known disease."
    (Barrows' dialogue)
  96. Lone Wanderer: "Doc, it's crowded in your clinic. Something going around I should worry about?"
    Doctor Church: "There's something going around, all right, but it isn't anything I've ever seen before. Definitely not contagious. Maybe something in the water, but that seems unlikely since I've tested it and this is the cleanest water we've ever had. I have no idea how to help these people and it's really taken the shine off my normally sunny disposition."
    (Church's dialogue)
  97. The Institute terminal entries; FEV Terminal, Subject CM-153
  98. Preston Garvey: "Those Super Mutants have been raiding across the Commonwealth for years. I'm glad to have the Brotherhood's help clearing them out."
    (Preston Garvey's dialogue)
  99. Brian Virgil Personal Log 0176
  100. The Institute terminal entries; FEV Lab Entry Terminal, Project Synthesis
  101. Fallout 4 loading screens: "The Institute's experiments with the Forced Evolutionary Virus, or FEV, ended when Doctor Virgil went rogue and fled into the Commonwealth."
  102. The Institute terminal entries; Institute Advanced Systems, Personal Notes

Non-canon

  1. Fallout 2 Official Strategies & Secrets p.26: "Many years ago, the Master, an insane doctor who attempted to become master of all humanity, tried to create guardians through gene splicing. The original Vault Dweller, your ancestor, stopped him before he could complete his plans. Unfortunately, some of his extra- ordinarily tough creations have oudived him and continue to roam the Wastes. Centaurs and Floaters are often found together, as though they feel some sort of kin- ship for one another."
  2. 2.0 2.1 Fallout Bible 5
  3. 3.0 3.1 Fallout Bible 3
  4. Fallout Bible 0: "2235 The Enclave experiments on deathclaws, attempting to create special fighting units for waging war in hostile environments."
  5. Fallout Bible 0: "2076 January 26 Using batch 11-011, experiments are conducted on raccoons. Same results are noted, but the attempted escape of several infected raccoons causes Major Barnett to terminate the escape... and the test subjects. Two pairs of raccoons, however, are unaccounted for."
    "Note: Scott Campbell and Chris Taylor intended these escaped raccoons to form an intelligent animal community NW of the Glow called the "Burrows." This location was never implemented."
  6. Fallout Bible 0: "2102 May 22 Increasing mutant attacks on Harold's caravans cause Harold to get so pissed he finances one of the first adventuring parties of Fallout to try and find out where these dagnab mutants are coming from. Consulting with a scientist and doctor at the Hub, a man by the name of Grey, the two of them decide to join forces.
    2102 June 23 Richard Grey's Expedition [including Harold] finds the Mariposa Military Base and the Expedition is scattered and defeated by mutants at the base. Grey is knocked into one of the vats of FEV by a robotic arm, and Harold is knocked unconscious, only to awaken later out in the wasteland.
    2102 June 27 Harold, already mutating, is found by traders and taken back to the Hub. His former caravan partners and employees, horrified by his condition, abandon him and he is soon left without even two bottlecaps to rub together.
    2102 July Richard Grey, now horribly mutated by the virus, crawls from the Vats covered with FEV and in terrible pain. Barely able to think or perceive his surroundings, he crawls into the Vat control room and begins his audio log. He fades in and out of consciousness, sometimes for days or weeks at a time.
    2102 July-Nov Richard Grey begins to acclimate to his condition, and begins his first tests of animals by exposing them to FEV. These experiments and his growing awareness lay the foundation for his plans for the Unity and the master race. He takes the name, 'the Master.'"
  7. Fallout Bible 0: "2102 Nov The first human victim wanders into Mariposa, and Grey consumes him.
    2102 Dec Grey continues his experiments on wanderers that enter Mariposa... with no success. The creations are flawed (due to the radiation counts in their bodies), making them big but incredibly stupid, and Grey consumes them rather than letting them live."
  8. Fallout Bible 0: "2103 January The Master discovers the problem with the influence of radiation on his mutations, and he begins to choose his subjects more carefully. The first classic super mutants are born, butt-scratching animations and all. He begins his plans to build an army."
  9. Fallout Bible 0: "2103-2130 Throughout this period, the Master begins slowly gathering test subjects, willing or unwilling, from local human stock. The Great Winter of 2130 and the scarcity of human subjects make building his army difficult."
  10. Fallout Bible 0: "2131-2135 The Master begins ordering his super mutants to gather human stock from caravans. For many years, the caravan disappearances are blamed on monsters in the desert, and even when the abductions begin to occur on Hub caravans, the deathclaws are blamed. The super mutant army grows."
  11. Fallout Bible 0: "2137 Master begins to mass-produce super mutants. Only about one in six or one in five attempts are successful, and of these successes, only half seem to last to go on to be part of his growing army, called the Unity."
  12. Fallout Bible 0: "2152 As their influence slowly spreads throughout the wastes, the Master finds humans, doomsday cultists, and rather than dip them in the vats, he demands their obedience as spies - their leader is a man named Morpheus, and he pledges his followers to the Master. Morpheus and his cultists form the future core of the Children of the Cathedral."
  13. Fallout Bible 0: "2156 The Master sees advantages in establishing a benevolent "religion," the Children of the Cathedral, and using them as spies in settlements throughout the wastes. Missionaries from the Children of the Cathedral spread slowly across the wasteland, acting as eyes and ears for Morpheus and the Master."
  14. Fallout Bible 0: "2155-2156 After capturing a caravan of strange-garbed travelers (Vault dwellers), Master learns the location of the Boneyard Vault, the future site of the Cathedral. He conquers the inhabitants and sets up operations there, and the human cultists begin to use the Vault as their powerbase. Within the Vault, the Master learns of other Vaults, and realizing their human occupants are ripe for transformation, begins to send out patrols to Vault locations in search of these other Vaults."
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