Radio stations can be tuned in to using the Pip-Boy 2000 Mark VI in Appalachia. Some of these radio stations allow for certain game mechanics to be changed while listening to the station. One radio station, Peacetime Radio, appeared in pre-release footage of the game, but was cut. Others were added with updates to the game.
Four radio stations can be received all across Appalachia. The Classical and Appalachia Radio play music, while the Hunter/Hunted Station initiates the Hunter/Hunted PVP mode. Rose's Radio is about chem monologues.