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For the condition that lists diseases in Fallout 76, see Fallout 76 diseases.
This page lists all mutations in Fallout 76.
  • The content is not described in full detail on this page. For details, please see the respective articles.
  • For mutations in other Fallout games, please see "Mutation."
  • For an overview of Fallout 76 content, please refer to "Portal:Fallout 76."

General informationEdit

Radiation has given you a Mutation! You gain positive and negative effects. Using RadAway has a chance to cure any Mutations.— Notification
FO76 Mutated

Fallout 76 alters the way radiation works. Instead of only limiting SPECIAL stats or max health, it allows the player character to develop various mutations, which act like traits in other games in the series. Mutations are a type of condition that give a mixture of powerful positive and negative effects. The Class Freak perk will reduce the negative effects of a mutation by up to 75%, while Strange in Numbers will grant a 25% increase to the positive effect if teammates are also mutated.

It is also possible to acquire up to 18 of the 19 available mutations at the same time. The sole exception is Carnivore and Herbivore, which prevent one another from being acquired. A player character wielding a legendary weapon with the Mutant's prefix will do 10% more damage when mutated.


Whenever one takes Radiation damage, they have a chance to gain a Mutation, equivalent to 5% per 5 points of radiation damage (if they are not below level 5). This can occur from being struck by excessive background radiation from a source such as zones devastated by nukes, irradiated creatures, radioactive waste, etc. Mutations may also be gained by consuming a mutation serum which allows a specific mutation to be gained.


Serums are consumable items that will grant a specific Mutation as one uses it, and temporarily suppresses the negative effects of the Mutation.

All serums and their recipes are sold by the MODUS science terminal at the Whitespring bunker Science Wing terminal. Recipes for the serums can also be purchased from MODUS but have a steep base price of 23000 caps each, but with the Hard Bargain Perk card and higher Charisma levels, the price can be reduced.

Prior to patch, mutation serum recipes also had a chance to be dropped by the scorchbeast queen.

Prevention and removalEdit

Mutations are semi-permanent. Every time the player character uses RadAway or a decontamination shower, there is a chance that a Mutation will be removed. They can keep using RadAway for more attempts to remove a Mutation. Radiation protection gear (e.g. hazmat suit) reduces the chance of mutation.

The Starched Genes perk allows for locking mutations, as it reduces/eliminates both the chance of becoming mutated and their removal chance. Mutations cannot be removed through death. However, a percentage of rads is removed through each death, so it's possible to mostly but not completely decontaminate oneself through multiple deaths if Starched Genes is not yet acquired. Nuka-Grape or brahmin milk can also be used to remove rads without risk of curing mutations.


Even with the Starched Genes perk, a Mutation's effects can be suppressed for a time with the use Rad-X. The suppression lasts for 10 minutes. To avoid the suppression effects of Rad-X, the diluted version or RadShield can be used. If one already has a mutation, the respective serum will suppress the negative effects of the Mutation for 60 minutes. For example, consuming a marsupial serum while already having the Marsupial mutation will remove the intelligence debuff.

Mutations listEdit

A player character can be affected by these mutations:

Mutation Positive Effect(s) Negative Effect(s) Serum Recipe Base ID
Adrenal Reaction +Weapon DMG at low HP Max HP -50 Adrenal reaction serum 004e1f14
Bird Bones AGI +4, Fall from heights more gradual STR -4, effectively gives the player Bone Worms Bird bones serum 003c403d
Carnivore Eating meat provides double the hunger satisfaction, HP restoration, and consumable buffs, with no disease chance. Eating plant-based food does not satisfy hunger, restore HP, or apply buffs. Carnivore serum 003c4049
Chameleon Invisibility in combat if unarmored and standing still Must have a weapon drawn, have no armor pieces equipped, stationary, and not attacking for effect to work. Armor pieces with the Weightless legendary attribute do not count as armor for the purposes of this mutation. Also, it is still possible for enemies to find you. Chameleon serum 004e4006
Eagle Eyes Critical Damage +25%, PER +4 STR -4 Eagle eyes serum 003c4037
Egg Head INT +6 STR -3, END -3 Egg head serum 003c4045
Electrically Charged Chance to shock melee attackers Small amount of damage done to player Electrically charged serum 004e400d
Empath Teammates take 25% less damage Player takes 33% more damage Empath serum 004e1f16
Grounded Energy Resistance +100 Energy Damage -50% Grounded serum 004e4002
Healing Factor Health Regeneration while not in combat +300% Chem Effects -55% Healing factor serum 004df1db
Herbivore Eating plant-based food provides double the hunger satisfaction, HP restoration, and consumable buffs, with no rads or disease chance. Eating meat does not satisfy hunger, restore HP, or apply buffs. Herbivore serum 003c404e
Herd Mentality All SPECIAL stats +2 when grouped. All SPECIAL stats -2 when solo. Herd mentality serum 004e1f1e
Marsupial Carry weight +20, +jump height INT -4 Marsupial serum 004df1ce
Plague Walker Poison aura scaling with your diseases. Diseases cannot cure themselves. Plague walker serum 004e4021
Scaly Skin Damage and Energy Resistance +50 AP -50 Scaly skin serum 004df1cf
Speed Demon Movement speed +20%, faster reload +20% +50% drain on hunger and thirst while moving. Speed demon serum 004df1e0
Talons Punching attacks do 25% more damage + bleed damage AGI -4 Talons serum 0028d3bc
Twisted Muscles Melee damage +25%, better chance to cripple limbs Gun accuracy -50% Twisted muscles serum 003c402f
Unstable Isotope Medium chance to release a radiation blast when struck in melee. Minor damage to player during the radiation blast Unstable isotope serum 004e4017


  • PCIcon pc Playstation 4Icon ps4 Xbox OneIcon xboxone The Class Freak perk card seems to have a bug on the effects page of the Pip-Boy, where it isn't showing any reduction to the Empath and Herd Mentality negative effects while it is for the other mutations. For the Herd Mentality it seems only a visual bug, the negative effect of having SPECIAL reduced by 2 when solo and in a combination of rank 3 Class Freak doesn't reduce SPECIAL at all when equipped. For the Empath negative effect, this is a confirmed bug, the +33% of damage is not reduced at all.[verified]
  • PCIcon pc Playstation 4Icon ps4 Xbox OneIcon xboxone Chameleon often glitches, and will render the character invisible from the player regardless of whether or not they're holding their weapon, wearing armor, or in motion. At times even just the character's exposed skin is rendered invisible, while their clothing remains visible.[verified]
  • PCIcon pc Playstation 4Icon ps4 Xbox OneIcon xboxone The Grounded mutation with the Class Freak perk (sometimes) says energy guns do 12% less damage (the correct amount) sometimes it says 50% less damage (the standard amount) but the energy gun damage is always 50% less.[verified]
  • PCIcon pc Playstation 4Icon ps4 Xbox OneIcon xboxone The Strange in Numbers perk can increase the effect of some mutations significantly. For example, combining it with the "Bird Bones" mutation can cause the player's fall speed to be reduced so much that it is possible to walk on air.[verified]
  • PCIcon pc Playstation 4Icon ps4 Xbox OneIcon xboxone The Herd Mentality mutation can prevent the sharing of other perk cards with the group. This appears to be fixed in the December 11th patch[verified]
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