Fallout 76 legendary weapon effects

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This page describes the Legendary effects applicable to weapons.

Legendary weapon effects

Note: for specific technical information, click the reference notes.

1-star

★

Name	Description	Notes	Availability	Form ID
Anti-Armor	Ignores 50% of your target's armor.	^{[note 1]}	–	005281B4
Anti-Armor 005281B4		Ignores 50% of your target's armor.^{[note 1]}
Aristocrat's	Damage increases as caps increases	^{[note 2]}	–	00606B71
Aristocrat's 00606B71		Damage increases as caps increases^{[note 2]}
Assassin's	+50% damage to Humans	^{[note 3]}	–	004F5770
Assassin's 004F5770		+50% damage to Humans^{[note 3]}
Berserker's	Lower Damage Resistance increases damage dealt	^{[note 4]}	–	004F6AA7
Berserker's 004F6AA7		Lower Damage Resistance increases damage dealt^{[note 4]}
Bloodied	Damage increases as health decreases	^{[note 5]}	–	004F6AA0
Bloodied 004F6AA0		Damage increases as health decreases^{[note 5]}
Executioner's	+50% damage when your target is below 40% health	^{[note 6]}	–	004F6AA1
Executioner's 004F6AA1		+50% damage when your target is below 40% health^{[note 6]}
Exterminator's	+50% damage to Mirelurks and bugs.	^{[note 7]}	–	001F81EB
Exterminator's 001F81EB		+50% damage to Mirelurks and bugs.^{[note 7]}
Furious	Damage increased after each consecutive hit on the same target	^{[note 8]}	–	004F577D
Furious 004F577D		Damage increased after each consecutive hit on the same target^{[note 8]}
Ghoul Slayer's	+50% damage to ghouls	^{[note 9]}	–	004F5779
Ghoul Slayer's 004F5779		+50% damage to ghouls^{[note 9]}
Gourmand's	Damage increases as you fill your hunger and thirst meters	^{[note 10]}	–	006069F2
Gourmand's 006069F2		Damage increases as you fill your hunger and thirst meters^{[note 10]}
Hunter's	+50% damage to animals	^{[note 11]}	–	004F577A
Hunter's 004F577A		+50% damage to animals^{[note 11]}
Instigating	Double damage if target is full health	^{[note 12]}	–	004F6AA5
Instigating 004F6AA5		Double damage if target is full health^{[note 12]}
Juggernaut's	Damage increases as health increases	^{[note 13]}	–	00606B73
Juggernaut's 00606B73		Damage increases as health increases^{[note 13]}
Junkie's	Damage increases when suffering from addictions	^{[note 14]}	–	004F6AAB
Junkie's 004F6AAB		Damage increases when suffering from addictions^{[note 14]}
Mutant's	Damage increased by 5% for each mutation	^{[note 15]}	–	005299F5
Mutant's 005299F5		Damage increased by 5% for each mutation^{[note 15]}
Mutant Slayer's	+50% damage to super mutants	^{[note 16]}	–	004F577B
Mutant Slayer's 004F577B		+50% damage to super mutants^{[note 16]}
Nocturnal	Damage increases with the night	^{[note 17]}	–	004F6AAE
Nocturnal 004F6AAE		Damage increases with the night^{[note 17]}
Suppressor's	Reduce your target's damage output by 25% for 5s	^{[note 18]}	–	005281B8
Suppressor's 005281B8		Reduce your target's damage output by 25% for 5s^{[note 18]}
Troubleshooter's	+50% damage to robots	^{[note 19]}	–	004F577C
Troubleshooter's 004F577C		+50% damage to robots^{[note 19]}
Vampire's	Gain brief health regeneration when you hit an enemy	^{[note 20]}	–	00527F84
Vampire's 00527F84		Gain brief health regeneration when you hit an enemy^{[note 20]}
Zealot's	+50% damage to Scorched	^{[note 21]}	–	004ED02B
Zealot's 004ED02B		+50% damage to Scorched^{[note 21]}
Ranged-only
Medic's	V.A.T.S. crits will heal you and your group	^{[note 22]}	–	00527F8B
Medic's 00527F8B		V.A.T.S. crits will heal you and your group^{[note 22]}
Quad	Quadruple ammo capacity	^{[note 23]}	^{[availability 1]}	004F6AB1
Quad 004F6AB1 ^{[availability 1]}		Quadruple ammo capacity^{[note 23]}
Stalker's	If not in combat, +100% VATS accuracy at +50% AP cost	^{[note 24]}	^{[availability 2]}	004F6D77
Stalker's 004F6D77 ^{[availability 2]}		If not in combat, +100% VATS accuracy at +50% AP cost^{[note 24]}
Two Shot	Shoots an additional projectile	^{[note 25]}	–	004F6D76
Two Shot 004F6D76		Shoots an additional projectile^{[note 25]}

2-star

★★

Name	Description	Notes	Availability	Form ID
Crippling	+50% limb damage	^{[note 26]}	–	004ED02C
Crippling 004ED02C		+50% limb damage^{[note 26]}
Inertial	Replenish AP with each kill	^{[note 27]}	–	00606B72
Inertial 00606B72		Replenish AP with each kill^{[note 27]}
Lucky	V.A.T.S. critical shots do +50% damage	^{[note 28]}	–	0052414B
Lucky 0052414B		V.A.T.S. critical shots do +50% damage^{[note 28]}
Ranged-only
Basher's	Bashing damage increased by 50%	^{[note 29]}	–	005299F9
Basher's 005299F9		Bashing damage increased by 50%^{[note 29]}
Explosive	Bullets explode for area damage	^{[note 30]}	^{[availability 3]}	004F5771 00425E28 (Shotguns)
Explosive 004F5771 00425E28 (Shotguns) ^{[availability 3]}		Bullets explode for area damage^{[note 30]}
Hitman's	+25% damage while aiming	^{[note 31]}	–	0052414E
Hitman's 0052414E		+25% damage while aiming^{[note 31]}
Last Shot	The last round in a magazine has a 25% chance to deal 2x DMG	^{[note 32]}	^{[availability 4]}	006069EC
Last Shot 006069EC ^{[availability 4]}		The last round in a magazine has a 25% chance to deal 2x DMG^{[note 32]}
Rapid	25% faster fire rate	–	–	0052414F
Rapid 0052414F		25% faster fire rate
VATS Enhanced	+50% VATS hit chance	^{[note 33]}	–	00524153
VATS Enhanced 00524153		+50% VATS hit chance^{[note 33]}
Melee-only
Melee Speed	40% faster swing speed	–	–	001A7BDA
Melee Speed 001A7BDA		40% faster swing speed
Power Attack Damage	40% more power attack damage	^{[note 34]}	–	001A7BE2
Power Attack Damage 001A7BE2		40% more power attack damage^{[note 34]}
Riposting	Reflects 50% of melee damage back while blocking	–	–	001A7C39
Riposting 001A7C39		Reflects 50% of melee damage back while blocking
Steady	+25% damage while standing still	^{[note 35]}	–	00606B71
Steady 00606B71		+25% damage while standing still^{[note 35]}

3-star

★★★

Name	Description	Notes	Availability	Form ID
Agility	+1 Agility	–	–	005299FB
Agility 005299FB		+1 Agility
Durability	Breaks 50% slower	–	–	0037F7D9
Durability 0037F7D9		Breaks 50% slower
Lightweight	90% reduced weight	^{[note 36]}	–	00524152
Lightweight 00524152		90% reduced weight^{[note 36]}
Lucky	Your V.A.T.S. critical meter fills 15% faster	–	–	0052414C
Lucky 0052414C		Your V.A.T.S. critical meter fills 15% faster
VATS Enhanced	25% less V.A.T.S. Action Point cost	–	–	00524154
VATS Enhanced 00524154		25% less V.A.T.S. Action Point cost
Ranged-only
Ghost's	Hits have a chance to generate a Stealth Field	^{[note 37]}	–	00609E4F
Ghost's 00609E4F		Hits have a chance to generate a Stealth Field^{[note 37]}
Nimble	Faster movement speed while aiming	^{[note 38]}	–	004ED02E
Nimble 004ED02E		Faster movement speed while aiming^{[note 38]}
Perception	+1 Perception	–	–	005299FA
Perception 005299FA		+1 Perception
Rapid	15% faster reload	–	–	00524150
Rapid 00524150		15% faster reload
Resilient	+250 Damage Resistance while reloading	–	–	004F5777
Resilient 004F5777		+250 Damage Resistance while reloading
Steadfast	+50 Damage Resistance while aiming	^{[note 39]}	–	004F5772
Steadfast 004F5772		+50 Damage Resistance while aiming^{[note 39]}
Melee-only
Cavalier's	Take 15% less damage while blocking	–	–	005253FB
Cavalier's 005253FB		Take 15% less damage while blocking
Cavalier's	Take 40% less damage while power attacking	^{[note 40]}	–	001A7BD3
Cavalier's 001A7BD3		Take 40% less damage while power attacking^{[note 40]}
Endurance	+1 Endurance	–	–	005299FD
Endurance 005299FD		+1 Endurance
Strength	+1 Strength	–	–	005299FC
Strength 005299FC		+1 Strength

Special effects

Special modifiers are in addition other effects, acting as a "zero-star legendary effect" on an item. This special modifier also supersedes the all above modifier names, if present; i.e. a harpoon gun will have both the Executioner's and Cursed modifiers and will be named a Cursed Harpoon Gun.

Special weapon effects

Name	Description	Notes	Availability	Form ID
Cursed	Improved damage, attack rate. Low durability.	^{[note 41]}	^{[availability 5]}	005A70C0 005A70C1 005A70C2 005FDE0D
Cursed 005A70C0 005A70C1 005A70C2 005FDE0D ^{[availability 5]}		Improved damage, attack rate. Low durability.^{[note 41]}

Cut effects

Cut effects

Name	Description	Notes	Availability	Form ID
Double	Double ammo capacity	^{[note 42]}	^{[availability 6]}	004392CD
Double 004392CD ^{[availability 6]}		Double ammo capacity^{[note 42]}
★★★★
Blazing Block	25% chance to deal 50 Fire damage on a successful block	–		00527F6D
Blazing Block 00527F6D		25% chance to deal 50 Fire damage on a successful block
Charged	10% chance to deal 40 Electrical damage on a successful block	–		001A7B88
Charged 001A7B88		10% chance to deal 40 Electrical damage on a successful block
Enraging	Critical hits cause target to frenzy	–		00527F6C
Enraging 00527F6C		Critical hits cause target to frenzy
Freezing	Critical hits freeze targets	–		005299FE
Freezing 005299FE		Critical hits freeze targets
Freezing Block	25% chance to freeze your opponent on a successful block	–		001A7B80
Freezing Block 001A7B80		25% chance to freeze your opponent on a successful block
Frenzying Block	10% chance to frenzy your opponent on a successful block	–		001A7AF6
Frenzying Block 001A7AF6		10% chance to frenzy your opponent on a successful block
Incendiary	Targets burn for 24 damage over 3 seconds	–	Perfect Storm	004F5773
Incendiary 004F5773 Perfect Storm		Targets burn for 24 damage over 3 seconds
Irradiating	50% chance to deal 50 Rads on a successful block	–		001A7AB2
Irradiating 001A7AB2		50% chance to deal 50 Rads on a successful block
Kneecapper	Chance to cripple a limb	–		00525401
Kneecapper 00525401		Chance to cripple a limb
Poisoner's	Target is poisoned for 50 damage over 10 seconds	–		004F5778
Poisoner's 004F5778		Target is poisoned for 50 damage over 10 seconds
Staggering	Chance to stagger on hit	–		00525400
Staggering 00525400		Chance to stagger on hit
Wounding	Targets bleed for 25 damage over 5 seconds	–		004ED02F
Wounding 004ED02F		Targets bleed for 25 damage over 5 seconds
★★★★★
Active	+10 Action Points	–	Civil Unrest	00529A04
Active 00529A04 Civil Unrest		+10 Action Points
Dangerous	20% more damage	–	Bunker Buster	00529A02
Dangerous 00529A02 Bunker Buster		20% more damage
Healthy	+10 Health	–	All Rise	00529A03
Healthy 00529A03 All Rise		+10 Health

Unique weapons

Unique weapons which come with predetermined legendary effects. They may be obtained as quest, event or challenge rewards. Others may be crafted.

Unique weapons
Item	Effects
Acceptable Overkill	Hunter's · Lucky · Perception
The Action Hero	Two-Shot · Rapid · Rapid
All Rise	Lightweight · Healthy
Bunker Buster	Dangerous
Civil Unrest	Active
Commander's Charge	Furious · Melee Speed · Agility
Crushing Blow	Instigating · Crippling
Disorderly Conduct	Suppressor's · Crippling · Endurance
Face Breaker	Furious · Power Attack Damage · Strength
The Fact Finder	Two-Shot · Explosive · VATS Enhanced
Fancy pump action shotgun	Anti-Armor · Crippling · Steadfast
Fancy single action revolver	Randomly-determined 1-star effect
The Farmhand	Ghoul-Slayer's · Melee Speed · Endurance
Final Word	Anti-Armor · Rapid · Resilient
The Fixer	(Hidden) Dangerous
The Guarantee	Instigating · Crippling · Rapid
The Gutter	Vampire's · (Hidden) Dangerous
Kingfisher	Exterminator's · Lucky · Lucky
Mechanic's Best Friend	Troubleshooter's · Power Attack Damage · Strength
Medical Malpractice	Medic's · VATS Enhanced · VATS Enhanced
Meteoritic sword	(Hidden) Assassin's · (Hidden) Weightless · (Hidden) Durable
Mind Over Matter	Ghoul-Slayer's · Hitman's · Steadfast
Nailer	Bloodied
Night Light	Nocturnal · Rapid · Perception
Oathbreaker	Suppressor's · Power Attack Damage · Cavalier's
Old Guard's 10mm SMG	Anti-Armor
Perfect Storm	Incendiery
Pyrolyzer	Suppressor's
The Quick Fix	Junkie's · Swing Speed · Endurance
Resolute Veteran	Suppressor's · Hitman's · Steadfast
Salt of the Earth	Two-Shot · Hitman's · Rapid
Slug Buster	Anti-Armor · Lucky · Lightweight
Sole Survivor	Assassin's · Hitman's · Steadfast
Somerset Special	Anti-Armor
Unstoppable Monster	Bloodied · Power Attack Damage · Cavalier's
The V.A.T.S. Unknown	Medic's · Lucky · Lucky
Whistle in the Dark	Nocturnal · VATS Enhanced · Perception

Notes

Technical notes

↑ Anti-Armor:
If armor penetration effects, such as the Stabilized or Tank Killer perks, are equipped, the armor reduction bonus is stacked multiplicatively with Anti-Armor.
↑ Aristocrat's:
0 ≤ Caps < 1000 = +0% Damage
1000 ≤ Caps < 2000 = +3% Damage
2000 ≤ Caps < 3000 = +5% Damage
3000 ≤ Caps < 4000 = +7% Damage
4000 ≤ Caps < 5000 = +8% Damage
5000 ≤ Caps < 6000 = +10% Damage
6000 ≤ Caps < 7000 = +12% Damage
7000 ≤ Caps < 8000 = +13% Damage
8000 ≤ Caps < 9000 = +15% Damage
9000 ≤ Caps < 10000 = +17% Damage
10000 ≤ Caps < 11000 = +18% Damage
11000 ≤ Caps < 12000 = +20% Damage
12000 ≤ Caps < 13000 = +22% Damage
13000 ≤ Caps < 14000 = +23% Damage
14000 ≤ Caps < 15000 = +25% Damage
15000 ≤ Caps < 16000 = +27% Damage
16000 ≤ Caps < 17000 = +28% Damage
17000 ≤ Caps < 18000 = +30% Damage
18000 ≤ Caps < 19000 = +32% Damage
19000 ≤ Caps < 20000 = +33% Damage
20000 ≤ Caps < 21000 = +35% Damage
21000 ≤ Caps < 22000 = +37% Damage
22000 ≤ Caps < 23000 = +38% Damage
23000 ≤ Caps < 24000 = +40% Damage
24000 ≤ Caps < 25000 = +42% Damage
25000 ≤ Caps < 26000 = +43% Damage
26000 ≤ Caps < 27000 = +45% Damage
27000 ≤ Caps < 28000 = +47% Damage
28000 ≤ Caps < 29000 = +48% Damage
29000 ≤ Caps < 30000 = +50% Damage
30000 ≤ Caps ≤ 40000 = +50% Damage
↑ Assassin's:
Applies to both humans and players
↑ Berserker's:
0 = DR = +50% Damage
0 < DR ≤ 20 = +30% Damage
20 < DR ≤ 40 = +17% Damage
40 < DR ≤ 60 = +5% Damage
60 < DR = +0% Damage
↑ Bloodied:
90% < HP ≤ 95% = +5% Damage
85% < HP ≤ 90% = +10% Damage
80% < HP ≤ 85% = +15% Damage
75% < HP ≤ 80% = +20% Damage
70% < HP ≤ 75% = +25% Damage
65% < HP ≤ 70% = +30% Damage
60% < HP ≤ 65% = +35% Damage
55% < HP ≤ 60% = +40% Damage
50% < HP ≤ 55% = +45% Damage
45% < HP ≤ 50% = +50% Damage
40% < HP ≤ 45% = +55% Damage
35% < HP ≤ 40% = +60% Damage
30% < HP ≤ 35% = +65% Damage
25% < HP ≤ 30% = +70% Damage
20% < HP ≤ 25% = +75% Damage
15% < HP ≤ 20% = +80% Damage
10% < HP ≤ 15% = +85% Damage
5% < HP ≤ 10% = +90% Damage
0% < HP ≤ 5% = +95% Damage
↑ Executioner's:
↑ Exterminator's:
Does not apply to hermit crabs
↑
Furious:
+5% damage per stack; nine stacks maximum for a total of +45% damage.
- Stacks reset to 0 after not hitting the target for 10 seconds, but are not lost on missed attacks.
- Stacks are reset on target swap, although the first attack on a new target may obtain the damage boost before resetting.
- Shotguns and other multiple-projectile weapons count each individual "hit" as a stack.
  - Example: When using a shotgun with the explosive effect (16 total "hits"), if 9 or more "hits" from the first shot hit one creature, the second shot will receive the full +45% damage bonus.
    Further reading
↑ Ghoul Slayer's:
Applies to both human ghouls and feral ghouls. Does not apply to wendigos, wendigo colossus or radstag ghoul / yaoguai ghoul.
↑ Gourmand's:
Damage bonuses from hunger and thirst are added together separately
+12% Damage from Fully Fed and +12% Damage from Fully Hydrated
0-20% fill = +0% Damage
21-40% fill = +3% Damage
41-60% fill = +6% Damage
61-80% fill = +9% Damage
81-100% fill = +12% Damage
↑ Hunter's:
Applies to all animals except deathclaws. Applies to scorchbeasts and all scorched animals.
↑ Instigating:
+100% base damage; does not deal double damage
↑ Juggernaut's:
0% < HP < 5% = +0% Damage
5% ≤ HP = +1% Damage
10% < HP ≤ 15% = +3% Damage
15% < HP ≤ 20% = +4% Damage
20% < HP ≤ 25% = +6% Damage
25% < HP ≤ 30% = +7% Damage
30% < HP ≤ 35% = +8% Damage
35% < HP ≤ 40% = +9% Damage
40% < HP ≤ 45% = +10% Damage
45% < HP ≤ 50% = +12% Damage
50% < HP ≤ 55% = +13% Damage
55% < HP ≤ 60% = +15% Damage
60% < HP ≤ 65% = +16% Damage
65% < HP ≤ 70% = +17% Damage
70% < HP ≤ 75% = +18% Damage
75% < HP ≤ 80% = +19% Damage
80% < HP ≤ 85% = +21% Damage
85% < HP ≤ 90% = +22% Damage
90% < HP ≤ 95% = +23% Damage
95% ≤ HP ≤ 100% = +25% Damage
↑ Junkie's:
Less than 5 active addictions: +10% Damage for each one
5 or more active addictions: +50% Damage
↑ Mutant's:
Stacks up to +25% damage at 5 or more mutations
↑ Mutant Slayer's:
Applies to Super Mutants and Super Mutant Behemoths only.
↑ Nocturnal:
+50% damage between 9:00 PM and 5:59 AM (in-game time)
↑ Suppressor's:
↑ Troubleshooter's:
Robots and turrets
↑ Vampire's:
Heals limb damage. Gives 1% of hp for 2 seconds.
Shotguns and other multiple projectile weapons heal per each projectile. For example if 8 projectiles hit a creature, player will be healed for total 16% of hp.
↑ Zealot's:
Applies to all scorched creatures, Scorched and Scorchbeasts.
↑ Medic's:
Heals 5 HP per second for 1 second
↑ Quad:
Increases clip size by +300% base value
↑ Stalker's:
Multiplicative: ×2.0 VATS accuracy and ×2.0 AP Cost
Does not actually cost +50% AP
Not in combat means that combat music is not playing, or the player has not been detected
↑ Two Shot:
+25% Damage and adds an extra projectile, splitting weapon damage across all projectiles.
↑ Crippling
Additive
Only increases limb condition damage, not actual damage dealt to HP bar
↑ Inertial:
+15 AP per kill
↑ Lucky (damage)
Additive
↑ Basher's:
Multiplicative: Bash damage x1.5
↑ Explosive:
Projectile overridden; will now explode for 20% base damage
Reduces accuracy in VATS and increases spread
Damage is not divided between projectiles, each deals 20% base damage (or, multiplied by # projectiles)
Shotguns-only: explosions deal 3% base damage
BUG: Energy/Radiation/Poison/Fire/Cryo damage explosions deal 100% base damage
↑ Hitman's:
Additive: +25% damage
Applies while aiming down with iron/glow/reflex sights; will not apply when using VATS or aiming with a scope.
↑ Last Shot:
Additive: +100% damage
BUG: not ×2.0 damage
↑ VATS Enhanced (accuracy):
Multiplicative: VATS hit chance x1.5
↑ Power Attack Damage:
Additive: +40% damage while power attacking
↑ Steady:
Additive: +25% Melee Damage
Standing still means not moving; still works while sneaking, jumping or jetpacking
↑ Lightweight:
Does not apply to weight added by weapon mods.
↑ Ghost's:
10% chance to grant invisibility for 2 seconds
↑ Nimble:
+100% movespeed while aiming
Applies while aiming down with iron sights, glow sights or reflex sights; will not apply when aiming with VATS or with a scope.
↑ Steadfast:
Applies while aiming down with iron sights, glow sights or reflex sights. Will not apply when aiming with VATS or with a scope.
↑ Cavalier's (power attack):
Increases all damage, not just melee attack damage
↑ Cursed:
+15% damage, +20% swing speed/fire rate, -4 durability
Blocks the ability to be Legendary Crafted
↑ Double:
Increases clip size by 100% base value

Availability and restrictions

↑ Quad:
Excludes single-shot weapons: Fat Man, missile launcher, M79 grenade launcher, black powder weapons (blunderbuss, dragon, pistol and rifle), bows, crossbows and compound bows. Is not intended to drop on "core" weapons (laser gatling, ultracite laser gatling and plasma gatling), however, these may drop from Ally daily quests and will have no impact on ammo capacity. No longer drops on crossbows. May now drop on all automatic weapons (no "cores").
↑ Stalker's:
No longer available on melee weapons.
↑ Explosive:
Cannot drop on energy weapons, explosive weapons or bows (see list)
↑ Last Shot:
No single-shot weapons; such as bows or black powder weapons.
BUG: may drop on the M79 grenade launcher.
↑ Cursed:
A Colossal Problem: (Harpoon gun · Pickaxe · Shovel)
Mole miner pails: (Rolling pin)
↑ Legacy content
Did not drop on melee weapons, Fat Man, missile launcher, grenade launchers, gamma gun, ultracite gatling laser and black powder weapons.

Explosive blacklist
Alien blaster	Auto grenade launcher	Bow
Broadsider	Compound bow	Crossbow
Cryolator	Enclave plasma gun	Fat Man
Flamer	Gamma gun	Gatling laser
Gatling plasma	Gauss minigun	Gauss pistol
Gauss rifle	Gauss shotgun^[1]	Harpoon gun
Hellstorm missile launcher	Laser gun	M79 grenade launcher
Missile launcher	Pepper Shaker	Plasma caster
Plasma gun	Radium rifle	Salvaged Assaultron head
Tesla rifle	Ultracite gatling laser	Ultracite laser gun

Changelog

Update 28

Assassin's - damage increased from +30% to +50%; no longer has a 25% chance of not applying in combat.
Basher's - damage increased from +40% to +50%.
Berserker's - reworked; removed damage debuff when Damage Resistance is ≥ 80 and reduced damage buff when Damage Resistance is between 1 and 60.
Enhanced VATS (accuracy) - VATS hit chance increased from +33% to +50%.
Exterminator's - damage increased from +30% to +50%.
Ghoul Slayer's - damage increased from +30% to +50%.
Hitman's - damage increased from +10% to +25%.
Hunter's - damage increased from +30% to +50%.
Mutant's - reworked; damage increases by +5% per Mutation, up to a maximum of +25% (5 Mutations).
Mutant Slayer's - damage increased from +30% to +50%.
Nocturnal - reworked; removed damage debuff during the day and damage is increased by +50% during the entire night.
Suppressor's - damage debuff effect increased from 20% for 3 seconds to 25% for 5 seconds.
Troubleshooter's - damage increased from +30% to +50%.
Zealot's - damage increased from +30% to +50%.
Aristocrat's - new
Juggernaut's - new
Gourmand's - new
Laser Shot - new
Steady - new
Inertial - new
Ghost's - new

Update 24

Exterminator's - now affects cave crickets.

Update 22

Assassin's - now affects human NPCs.^[2]

Update 9

Assassin's - reduced the chance of the legendary effect applying in combat from 100% to 75%.

Update 5

Explosive - reduced the damage bonus from +100% to +20% of base weapon damage, with explosive radius damage.
Explosive (shotguns) - reduced the damage bonus from +100% to +3% of base weapon damage, with explosive radius damage.
Two Shot - reduced the damage bonus from +100% to +25% of base weapon damage.

References

↑ Can be obtained as from Ally: Get the Item daily quests, due to bug
↑ This change set the Assassin's effect to apply against the HumanRace "Human" [RACE:00013746], which includes Player [NPC_: 00000007] and Human NPCs.

[1] Anti-Armor:
If armor penetration effects, such as the Stabilized or Tank Killer perks, are equipped, the armor reduction bonus is stacked multiplicatively with Anti-Armor.

[2] Aristocrat's:
0 ≤ Caps < 1000 = +0% Damage
1000 ≤ Caps < 2000 = +3% Damage
2000 ≤ Caps < 3000 = +5% Damage
3000 ≤ Caps < 4000 = +7% Damage
4000 ≤ Caps < 5000 = +8% Damage
5000 ≤ Caps < 6000 = +10% Damage
6000 ≤ Caps < 7000 = +12% Damage
7000 ≤ Caps < 8000 = +13% Damage
8000 ≤ Caps < 9000 = +15% Damage
9000 ≤ Caps < 10000 = +17% Damage
10000 ≤ Caps < 11000 = +18% Damage
11000 ≤ Caps < 12000 = +20% Damage
12000 ≤ Caps < 13000 = +22% Damage
13000 ≤ Caps < 14000 = +23% Damage
14000 ≤ Caps < 15000 = +25% Damage
15000 ≤ Caps < 16000 = +27% Damage
16000 ≤ Caps < 17000 = +28% Damage
17000 ≤ Caps < 18000 = +30% Damage
18000 ≤ Caps < 19000 = +32% Damage
19000 ≤ Caps < 20000 = +33% Damage
20000 ≤ Caps < 21000 = +35% Damage
21000 ≤ Caps < 22000 = +37% Damage
22000 ≤ Caps < 23000 = +38% Damage
23000 ≤ Caps < 24000 = +40% Damage
24000 ≤ Caps < 25000 = +42% Damage
25000 ≤ Caps < 26000 = +43% Damage
26000 ≤ Caps < 27000 = +45% Damage
27000 ≤ Caps < 28000 = +47% Damage
28000 ≤ Caps < 29000 = +48% Damage
29000 ≤ Caps < 30000 = +50% Damage
30000 ≤ Caps ≤ 40000 = +50% Damage

[3] Assassin's:
Applies to both humans and players

[4] Berserker's:
0 = DR = +50% Damage
0 < DR ≤ 20 = +30% Damage
20 < DR ≤ 40 = +17% Damage
40 < DR ≤ 60 = +5% Damage
60 < DR = +0% Damage

[5] Bloodied:
90% < HP ≤ 95% = +5% Damage
85% < HP ≤ 90% = +10% Damage
80% < HP ≤ 85% = +15% Damage
75% < HP ≤ 80% = +20% Damage
70% < HP ≤ 75% = +25% Damage
65% < HP ≤ 70% = +30% Damage
60% < HP ≤ 65% = +35% Damage
55% < HP ≤ 60% = +40% Damage
50% < HP ≤ 55% = +45% Damage
45% < HP ≤ 50% = +50% Damage
40% < HP ≤ 45% = +55% Damage
35% < HP ≤ 40% = +60% Damage
30% < HP ≤ 35% = +65% Damage
25% < HP ≤ 30% = +70% Damage
20% < HP ≤ 25% = +75% Damage
15% < HP ≤ 20% = +80% Damage
10% < HP ≤ 15% = +85% Damage
5% < HP ≤ 10% = +90% Damage
0% < HP ≤ 5% = +95% Damage

[6] Executioner's:

[7] Exterminator's:
Does not apply to hermit crabs

[8] Furious:
+5% damage per stack; nine stacks maximum for a total of +45% damage.
Stacks reset to 0 after not hitting the target for 10 seconds, but are not lost on missed attacks.

Stacks are reset on target swap, although the first attack on a new target may obtain the damage boost before resetting.

Shotguns and other multiple-projectile weapons count each individual "hit" as a stack.
Example: When using a shotgun with the explosive effect (16 total "hits"), if 9 or more "hits" from the first shot hit one creature, the second shot will receive the full +45% damage bonus.
Further reading

[9] Stacks reset to 0 after not hitting the target for 10 seconds, but are not lost on missed attacks.

[10] Stacks are reset on target swap, although the first attack on a new target may obtain the damage boost before resetting.

[11] Shotguns and other multiple-projectile weapons count each individual "hit" as a stack.
Example: When using a shotgun with the explosive effect (16 total "hits"), if 9 or more "hits" from the first shot hit one creature, the second shot will receive the full +45% damage bonus.
Further reading

[12] Example: When using a shotgun with the explosive effect (16 total "hits"), if 9 or more "hits" from the first shot hit one creature, the second shot will receive the full +45% damage bonus.
Further reading

[9] Ghoul Slayer's:
Applies to both human ghouls and feral ghouls. Does not apply to wendigos, wendigo colossus or radstag ghoul / yaoguai ghoul.

[10] Gourmand's:
Damage bonuses from hunger and thirst are added together separately
+12% Damage from Fully Fed and +12% Damage from Fully Hydrated
0-20% fill = +0% Damage
21-40% fill = +3% Damage
41-60% fill = +6% Damage
61-80% fill = +9% Damage
81-100% fill = +12% Damage

[11] Hunter's:
Applies to all animals except deathclaws. Applies to scorchbeasts and all scorched animals.

[12] Instigating:
+100% base damage; does not deal double damage

[13] Juggernaut's:
0% < HP < 5% = +0% Damage
5% ≤ HP = +1% Damage
10% < HP ≤ 15% = +3% Damage
15% < HP ≤ 20% = +4% Damage
20% < HP ≤ 25% = +6% Damage
25% < HP ≤ 30% = +7% Damage
30% < HP ≤ 35% = +8% Damage
35% < HP ≤ 40% = +9% Damage
40% < HP ≤ 45% = +10% Damage
45% < HP ≤ 50% = +12% Damage
50% < HP ≤ 55% = +13% Damage
55% < HP ≤ 60% = +15% Damage
60% < HP ≤ 65% = +16% Damage
65% < HP ≤ 70% = +17% Damage
70% < HP ≤ 75% = +18% Damage
75% < HP ≤ 80% = +19% Damage
80% < HP ≤ 85% = +21% Damage
85% < HP ≤ 90% = +22% Damage
90% < HP ≤ 95% = +23% Damage
95% ≤ HP ≤ 100% = +25% Damage

[14] Junkie's:
Less than 5 active addictions: +10% Damage for each one
5 or more active addictions: +50% Damage

[15] Mutant's:
Stacks up to +25% damage at 5 or more mutations

[16] Mutant Slayer's:
Applies to Super Mutants and Super Mutant Behemoths only.

[17] Nocturnal:
+50% damage between 9:00 PM and 5:59 AM (in-game time)

[18] Suppressor's:

[19] Troubleshooter's:
Robots and turrets

[20] Vampire's:
Heals limb damage. Gives 1% of hp for 2 seconds.
Shotguns and other multiple projectile weapons heal per each projectile. For example if 8 projectiles hit a creature, player will be healed for total 16% of hp.

[21] Zealot's:
Applies to all scorched creatures, Scorched and Scorchbeasts.

[22] Medic's:
Heals 5 HP per second for 1 second

[23] Quad:
Increases clip size by +300% base value

[25] Stalker's:
Multiplicative: ×2.0 VATS accuracy and ×2.0 AP Cost
Does not actually cost +50% AP
Not in combat means that combat music is not playing, or the player has not been detected

[27] Two Shot:
+25% Damage and adds an extra projectile, splitting weapon damage across all projectiles.

[28] Crippling
Additive
Only increases limb condition damage, not actual damage dealt to HP bar

[29] Inertial:
+15 AP per kill

[30] Lucky (damage)
Additive

[31] Basher's:
Multiplicative: Bash damage x1.5

[32] Explosive:
Projectile overridden; will now explode for 20% base damage
Reduces accuracy in VATS and increases spread
Damage is not divided between projectiles, each deals 20% base damage (or, multiplied by # projectiles)
Shotguns-only: explosions deal 3% base damage
BUG: Energy/Radiation/Poison/Fire/Cryo damage explosions deal 100% base damage

[34] Hitman's:
Additive: +25% damage
Applies while aiming down with iron/glow/reflex sights; will not apply when using VATS or aiming with a scope.

[35] Last Shot:
Additive: +100% damage
BUG: not ×2.0 damage

[37] VATS Enhanced (accuracy):
Multiplicative: VATS hit chance x1.5

[38] Power Attack Damage:
Additive: +40% damage while power attacking

[39] Steady:
Additive: +25% Melee Damage
Standing still means not moving; still works while sneaking, jumping or jetpacking

[40] Lightweight:
Does not apply to weight added by weapon mods.

[41] Ghost's:
10% chance to grant invisibility for 2 seconds

[42] Nimble:
+100% movespeed while aiming
Applies while aiming down with iron sights, glow sights or reflex sights; will not apply when aiming with VATS or with a scope.

[43] Steadfast:
Applies while aiming down with iron sights, glow sights or reflex sights. Will not apply when aiming with VATS or with a scope.

[44] Cavalier's (power attack):
Increases all damage, not just melee attack damage

[45] Cursed:
+15% damage, +20% swing speed/fire rate, -4 durability
Blocks the ability to be Legendary Crafted

[47] Double:
Increases clip size by 100% base value

[24] Quad:
Excludes single-shot weapons: Fat Man, missile launcher, M79 grenade launcher, black powder weapons (blunderbuss, dragon, pistol and rifle), bows, crossbows and compound bows. Is not intended to drop on "core" weapons (laser gatling, ultracite laser gatling and plasma gatling), however, these may drop from Ally daily quests and will have no impact on ammo capacity. No longer drops on crossbows. May now drop on all automatic weapons (no "cores").

[26] Stalker's:
No longer available on melee weapons.

[33] Explosive:
Cannot drop on energy weapons, explosive weapons or bows (see list)

[36] Last Shot:
No single-shot weapons; such as bows or black powder weapons.
BUG: may drop on the M79 grenade launcher.

[46] Cursed:
A Colossal Problem: (Harpoon gun · Pickaxe · Shovel)
Mole miner pails: (Rolling pin)

[48] Legacy content
Did not drop on melee weapons, Fat Man, missile launcher, grenade launchers, gamma gun, ultracite gatling laser and black powder weapons.

[49] Can be obtained as from Ally: Get the Item daily quests, due to bug

[50] This change set the Assassin's effect to apply against the HumanRace "Human" [RACE:00013746], which includes Player [NPC_: 00000007] and Human NPCs.

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