|For an overview, see diseases and viruses.|
When the player character consumes unclean food and liquid, there is a chance of acquiring a disease. Exposure to the elements, such as sleeping on floor mattresses, swimming in contaminated water or breathing toxic air, can also cause disease. They may also be contracted from contact with diseased creatures. Similar to mutations, diseases have a 30-minute cooldown for catching another disease or 45 minutes for the same disease. Leaving the server resets this cooldown so that another disease can immediately be obtained upon joining a different server.
Diseases can be avoided by cooking food, eating pre-War packaged food and drinking boiled or purified water. Sleeping on raised mattresses will never grant a disease, while sleeping on a floor mattress may inflict one. Avoid physical contact with diseased ( ) creatures, as each melee attack has a chance to inflict disease.
They may also be avoided by maintaining a character's food and water needs, as each increases the resistance of disease by 25%, or by 35% with the perk Rejuvenated. Taking antibiotics or consuming certain food and drink also temporarily increases disease resistance, but using RadAway will temporarily reduce disease resistance by 50%.
The perks Iron Stomach and Thirst Quencher greatly reduce the chance of disease from consumed food and liquid, respectively, while the perk Vaccinated protects against diseased creatures. The mutations herbivore and carnivore will grant immunity to disease when eating raw and spoiled plants or meat, respectively.
All diseases will naturally expire over time. A single disease can be cured early by using a disease cure or antibiotics, drinking from the sulfur water fountain at a white gazebo near the Whitespring Golf Club, or by entering the constructible Sympto-Matic. The C.A.M.P. ally Solomon Hardy will cure diseases for the C.A.M.P. owner.
|List of diseases|
|The Blight||-1 to all S.P.E.C.I.A.L stats||30 min||Inflicted by a diseased Scorchbeast, Grafton Monster, mega sloth or mirelurk queen.||004C6B3E|
|Blood worms||Take 25% more damage||15 min||Inflicted by a diseased radroach.||003DF043|
|Bone worms||Take 50% more limb damage||15 min||Inflicted by a diseased mole rat or radrat, or stepping on traps such as a punji board.||00008881|
|Buzz brain||INT -2||60 min||Inflicted by a diseased ant.||004C6B34|
|Dysentery||Periodic water loss||15 min||Eat raw carrots, spoiled meat, swim in toxic water.||00284956|
|Fever claw||-25% Damage with Melee Weapons||15 min||Inflicted by a diseased mirelurk hunter.||004C6B48|
|Flap limb||STR -2||60 min||Inflicted by a diseased mirelurk.||004C6B1F|
|Glowing pustules||Bleed radiation from wounds when hit||15 min||Inflicted by a diseased glowing one or radstag.||004B0095|
|Heat flashes||END -2||45 min||Inflicted by a diseased honey beast.||004C6B2A|
|Jelly fingers||+50% Ranged VATS AP Cost||15 min||Inflicted by a diseased stingwing.||003C75C4|
|Lock joint||Melee AP cost +50%||15 min||Inflicted by a diseased wolf.||003C75BE|
|Needle spine||-10 Carry Capacity||15 min||Inflicted by a diseased angler.||003C75B8|
|Parasites||Periodic food loss||15 min||Inflicted by a diseased tick or bloodbug, swimming in water, eating raw mutfruit, drinking cream.||00112E6D|
|Rad worms||Take 50% more radiation damage.||15 min||Inflicted by any feral ghoul or a diseased mutant hound.||003DF041|
|Rattle hands||-25% damage with ranged weapons||45 min||Inflicted by a diseased mirelurk king.||004C6B4F|
|Shell shock||Action Point drain from wounds||45 min||Inflicted by a diseased mongrel or deathclaw.||004B009C|
|Sludge lung||Max AP -50, AP regen -50||60 min||Inflicted by a diseased wendigo, or exposure to toxic air without wearing a gas mask, assault gas mask or spacesuit helmet.||0018EF92|
|Snot ear||PER -2||15 min||Inflicted by a diseased snallygaster or gulper.||004C6B25|
|Swamp gas||CHR -2||15 min||Inflicted by a diseased bloatfly.||004C6B2F|
|Swamp itch||AGI -2||15 min||Sleep in a sleeping bag/mattress on the ground.||003CD03B|
|Weeping sores||Bleed from wounds||45 min||Inflicted by diseased radscorpions or yao guai.||003DF045|
|The Woopsies||LCK -2||15 min||Inflicted by a diseased mirelurk spawn.||004C6B39|
|Scorched Plague||Take 5% more damage from Scorched enemies||? min||An Ounce of Prevention.Player is immune to acquiring it if they have completed||004C6B39|
- As of patch 220.127.116.11, the player character must be level 15 or higher to acquire a disease.
- As of patch 18.104.22.168, the penalty to having Fever Claw was changed from ranged weapons to melee weapons.
- Plague Walker mutation does not prevent the time-based expiration of diseases, which it claims to do. [patched]; confirmed to be a description error in January 26, 2021 patch. The
- challenge for acquiring all diseases is bugged and does not register Sludge Lung, whether it is acquired by breathing in the toxic air in the Ash Heap or acquired from a diseased wendigo.[verification overdue] The