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Each Disease has unique penalties. Use Disease Cures, Antibiotics, or wait until the Disease expires on its own.— In-game notification

Diseases are a type of negative condition in Fallout 76.


When the player character consumes unclean food and liquid, there is a chance of acquiring a disease. Exposure to the elements, such as sleeping on floor mattresses, swimming in contaminated water or breathing toxic air, can also cause disease. They may also be contracted from contact with diseased creatures. Similar to mutations, diseases have a 30-minute cooldown for catching another disease or 45 minutes for the same disease. Leaving the server resets this cooldown so that another disease can immediately be obtained upon joining a different server.


Fo76 Disease icon.png

Diseases can be avoided by cooking food, eating pre-War packaged food and drinking boiled or purified water. Sleeping on raised mattresses will never grant a disease, while sleeping on a floor mattress may inflict one. Avoid physical contact with diseased (Disease) creatures, as each melee attack has a chance to inflict disease.

They may also be avoided by maintaining a character's food and water needs, as each increases the resistance of disease by 25%, or by 35% with the perk Rejuvenated. Taking antibiotics or consuming certain food and drink also temporarily increases disease resistance, but using RadAway will temporarily reduce disease resistance by 50%.

The perks Iron Stomach and Thirst Quencher greatly reduce the chance of disease from consumed food and liquid, respectively, while the perk Vaccinated protects against diseased creatures. The mutations herbivore and carnivore will grant immunity to disease when eating raw and spoiled plants or meat, respectively.


All diseases will naturally expire over time. A single disease can be cured early by using a disease cure or antibiotics, drinking from the sulfur water fountain at a white gazebo near the Whitespring Golf Club, or by entering the constructible Sympto-Matic. The C.A.M.P. ally Solomon Hardy will cure diseases for the C.A.M.P. owner.


List of diseases
Disease Effect(s) Duration Cause Form ID
The Blight -1 to all S.P.E.C.I.A.L stats 30 min Inflicted by a diseased Scorchbeast, Grafton Monster, mega sloth or mirelurk queen. 004C6B3E
Blood worms Take 25% more damage 15 min Inflicted by a diseased radroach. 003DF043
Bone worms Take 50% more limb damage 15 min Inflicted by a diseased mole rat or radrat, or stepping on traps such as a punji board. 00008881
Buzz brain INT -2 60 min Inflicted by a diseased ant. 004C6B34
Dysentery Periodic water loss 15 min Eat raw carrots, spoiled meat, swim in toxic water. 00284956
Fever claw -25% Damage with Melee Weapons 15 min Inflicted by a diseased mirelurk hunter. 004C6B48
Flap limb STR -2 60 min Inflicted by a diseased mirelurk. 004C6B1F
Glowing pustules Bleed radiation from wounds when hit 15 min Inflicted by a diseased glowing one or radstag. 004B0095
Heat flashes END -2 45 min Inflicted by a diseased honey beast. 004C6B2A
Jelly fingers +50% Ranged VATS AP Cost 15 min Inflicted by a diseased stingwing. 003C75C4
Lock joint Melee AP cost +50% 15 min Inflicted by a diseased wolf. 003C75BE
Needle spine -10 Carry Capacity 15 min Inflicted by a diseased angler. 003C75B8
Parasites Periodic food loss 15 min Inflicted by a diseased tick or bloodbug, swimming in water, eating raw mutfruit, drinking cream. 00112E6D
Rad worms Take 50% more radiation damage. 15 min Inflicted by any feral ghoul or a diseased mutant hound. 003DF041
Rattle hands -25% damage with ranged weapons 45 min Inflicted by a diseased mirelurk king. 004C6B4F
Shell shock Action Point drain from wounds 45 min Inflicted by a diseased mongrel or deathclaw. 004B009C
Sludge lung Max AP -50, AP regen -50 60 min Inflicted by a diseased wendigo, or exposure to toxic air without wearing a gas mask, assault gas mask or spacesuit helmet. 0018EF92
Snot ear PER -2 15 min Inflicted by a diseased snallygaster or gulper. 004C6B25
Swamp gas CHR -2 15 min Inflicted by a diseased bloatfly. 004C6B2F
Swamp itch AGI -2 15 min Sleep in a sleeping bag/mattress on the ground. 003CD03B
Weeping sores Bleed from wounds 45 min Inflicted by diseased radscorpions or yao guai. 003DF045
The Woopsies LCK -2 15 min Inflicted by a diseased mirelurk spawn. 004C6B39
Cut content Scorched Plague Take 5% more damage from Scorched enemies ? min Cut content Player is immune to acquiring it if they have completed An Ounce of Prevention. 004C6B39


  • As of patch, the player character must be level 15 or higher to acquire a disease.
  • As of patch, the penalty to having Fever Claw was changed from ranged weapons to melee weapons.


  • PCPC Xbox OneXbox One Playstation 4Playstation 4 The Plague Walker mutation does not prevent the time-based expiration of diseases, which it claims to do. [patched]; confirmed to be a description error in January 26, 2021 patch.
  • PCPC Xbox OneXbox One Playstation 4Playstation 4 The challenge for acquiring all diseases is bugged and does not register Sludge Lung, whether it is acquired by breathing in the toxic air in the Ash Heap or acquired from a diseased wendigo.[verification overdue]