Icon disambig
For the condition that lists mutations, see mutations.
Each Disease has unique penalties. Use Disease Cures, Antibiotics, or wait until the Disease expires on its own.— In-game notification

Diseases are a type of condition in Fallout 76.

Causes and effectsEdit

Fo76 Disease icon

When the player character consumes unclean food and liquid, there is a chance of acquiring a disease. Being attacked by diseased creatures and sleeping on floor mattresses can also cause disease. Eating uncooked meat and drinking dirty water has the highest risks for disease.

Diseases cause a variety of effects including increased damage and needs, such as hunger.


Diseases can be avoided by cooking food, eating pre-War packaged food, and drinking boiled or purified water. Sleeping on raised mattresses and avoiding physical contact with diseased creatures will also avoid disease.

Maintaining a character's food and water needs increases resistance of disease by 25%, even more with the perk Rejuvenated. Taking RadAway or antibiotics also temporarily increases disease resistance. The perks Iron Stomach and Thirst Quencher greatly reduce the chance of disease from consumed food and liquid, respectively, while the perk Vaccinated protects against diseased creatures.


Diseases are time-limited and will expire. They can be cured prior to their expiration with disease cures or antibiotics. Alternatively, drinking from a sulfur water fountain (one is located at a white gazebo near The Whitespring Resort) will cure a disease.

Intentional diseasesEdit

Intentionally catching diseases will be useful with the Plague Walker mutation, in which case the player should reference the consumables and regions lists to become familiar with the best methods of quickly accumulating diseases.

List of diseasesEdit

A character can get infected by these diseases:

Disease Effect(s) Duration Base ID Cause
The Blight -1 to all S.P.E.C.I.A.L stats 30 min 004c6b3e Caught from a diseased Scorchbeast
Blood worms Take 25% more damage 15 min 003df043
Bone worms Take 50% more limb damage 15 min 00008881 Step on a punji board.
Buzz brain INT -2 60 min 004c6b34 Attacked by a glowing ant
Dysentery Periodic water loss 15 min 00284956
Eat raw carrots, spoiled meat, swim in toxic water
Fever claw -25% Damage with Ranged Weapons 15 min 004c6b48
Flap limb STR -2 60 min 004c6b1f
Glowing pustules Bleed radiation from wounds when hit 15 min 004b0095
Inflicted by a infected bloated glowing one.
Heat flashes END -2 45 min 004c6b2a
Jelly fingers +50% Ranged VATS AP Cost 15 min 003c75c4
Lock joint Melee AP cost +50% 15 min 003c75be
Needle spine -10 Carry Capacity 15 min 003c75b8 Caught from a diseased angler.
Parasites Periodic food loss 15 min 00112e6d Caught from a diseased tick, swimming in water, eating raw mutfruit, drinking cream.
Rad worms Take 50% more radiation damage. 15 min 003df041 Inflicted by a diseased feral ghoul stalker.
Rattle hands -25% damage with ranged weapons 45 min 004c6b4f
Shell shock Action Point drain from wounds 45 min 004b009c Inflicted by a diseased mongrel
Sludge lung Max AP -50, AP regen -50 60 min 0018ef92 Exposure to toxic air without wearing a gas mask, assault gas mask, or spacesuit helmet
Snot ear PER -2 15 min 004c6b25 Inflicted by a diseased snallygaster
Swamp gas CHR -2 15 min 004c6b2f Inflicted by a diseased bloatfly
Swamp itch AGI -2 15 min 003cd03b Sleep in a sleeping bag/mattress on the ground.
Weeping sores Bleed from wounds 45 min 003df045
The Woopsies LCK -2 15 min 004c6b39 Inflicted by a scorched ant during the scorchbeast queen encounter