The most common character conditions found in Fallout 76 are poisons from Chems or from the environment, and damage from combat. Fallout 76 is currently the only game besides Fallout 4 in the Fallout series to include diseases.
Similar to Fallout 4's Survival mode, player characters in Fallout 76 need food and water to survive. Depriving any of those needs will result in negative effects, while adequately satisfying them grants temporary positive effects.
Fallout 76 also features mutations that have a chance of occurring on exposure to radiation from consumables, creature attacks, and irradiated zones. Mutations have a chance of being cured with RadAway. To protect desired mutations from RadAway, player characters can equip the second rank of the perk Starched Genes.
Equipment condition returns in Fallout 76 from Fallout 3 and Fallout: New Vegas. The condition of equipment affects its value and its damage or protection. Unlike in previous games, armor and weapons can be repaired using junk and crafting components at an armor workbench or weapons workbench. Equipment cannot repaired without a workbench.