Attacks to the eye have an added Critical Chance which often requires the luck roll that if failed, blinds, lowering accuracy. Blindness affects Perception and most of the time the critical effect is fatal. The eyes are the hardest limb to hit, though.
Eye Damage in Fallout 2 cannot be healed by any of the in-game doctors, it requires a moderate level of the Doctor skill. A doctor's bag or equivalent is optional and could improve the chances.