Ethel was among those who retired to the Sandy Coves Convalescent Home. She was among the many there to experience her age; experiencing dementia, she (like the others dwelling there) would occasionally lose their safe key. Prompting their caregivers to program the Mister Handy robots to remember where they habitually hide it. In this case, beneath her paint brush. She occupied her time by painting; she was a talented painter and her work litters her room.
On the morning of Saturday, October 23, 2077 she was awake, when the radiation from the nuclear detonations swept through the facility killing the occupants where they were. Her skeleton lies in the corner of the room, clutching a painting.
Ethel appears as a skeleton in Fallout 4.