Before the Great War, Ella Ames earned a Ph.D. in medical science from Vault-Tec University and worked as a doctor. She also knowledge of holistic medicine taught to her by her mother. West Tek research center attempted to recruit Ella, but she turned them down and later joined the Free States. West Tek would later plan to use her father's failing health as an opportunity to pursue recruitment further. Ella also attended survival training at Camp Venture with a group of other Free States members in 2081. The trainer took special notice of her, noting her impressive skills around firearms, dressing game and even wrestling.
Ella survived the war in her personal bunker and subsequently provided vital medical services for the other members of the Free States. She also conducted research on the flora and fauna of the Mire, which had become much more heavily mutated than in other parts of Appalachia, and developed theories on their origins. She also extensively studied the scorched and the scorchbeasts following the Free States' loss of Harpers Ferry, and attempted preliminary work into analyzing new diseases and developing a radiation shield known as RadShield.
Ella Ames appears only in Fallout 76.