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Edwin may refer to:
- Edwin Brotch, a resident of Vault 101 and the vault's teacher in Fallout 3.
- Edwina Bell, the wife and widow of Carl Bell, mentioned in Fallout 3.
- Robert Edwin House, the self-styled President, CEO, and Sole Proprietor of the New Vegas Strip in Fallout: New Vegas.
- Edwin (Fallout 4), a deceased, skeletal man who lived at the Chestnut Hillock Reservoir in Fallout 4.
- Edwin Reed, an acupuncturist that resided in Vault 51, mentioned in the Fallout 76 update Nuclear Winter.
- Edwin, a gang leader in the Fallout 76 update Wastelanders.
- Real-life person:
- Edwin Stanton, an American lawyer and politician who served as Secretary of War, mentioned in Fallout 3.
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