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Duke may refer to:
- Duke, a slaver residing in The Pitt in the Fallout 3 add-on The Pitt.
- Duke, a Fiend residing in the South Vegas Ruins in Fallout: New Vegas.
- Duke, a member of the Atom Cats at the Atom Cats garage in Fallout 4.
- Duke, a member of the Forged, mentioned in Fallout 4.
- Duke, a dog at Horizon Flight 1207 in the Fallout 4 add-on Far Harbor.
- Duke Earl, a prisoner at Eastern Regional Penitentiary, mentioned in Fallout 76.
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