For other characters named Duff, see Duff.


Doctor Duff is a resident of Diamond City in 2287. She along with Professor Scara both work and reside in the Science! Center.


The open and easy-going Doctor Duff is the public face of the Science! Center, responsible for interacting with visitors and schoolchildren on field trips. She's a treasure trove of knowledge, particularly relating to biology, and doesn't shy away from sharing it with anyone willing to listen.[1] She is also very absent minded and impulsive - someone who would just start a project and have to apologize if it got in someone's way. That someone is usually her lover Professor Scara. The pair operate as the classic "odd couple."[2] While Duff has a multitude of experiments running simultaneously, Scara focuses on one at a time, even when Duff tries to get her to help her.[3] Duff has also has taken to cleaning up their home and laboratory, to the chagrin of Scara, who didn't want her laboratory space rearranged.[4]

During the quest Liberty Reprimed, Duff will ask the Sole Survivor to rescue Professor Scara from the General Atomics Galleria. With Scara's absence, Duff is depressed and uninterested in her work, feeling depressed at her not being present, and hopeful for her return.[5][6][7] Scara, joining the Brotherhood of Steel, leaves her without her partner.

Interactions with the player character

Interactions overview

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This character is involved in quests.


  • Liberty Reprimed: When the Sole Survivor travels to the Science! Center in search of Scara, she will request that they look for her at the General Atomics Galleria, worried that something might have happened to her.
  • Fly Fishing: After speaking to her about a free biology lesson, she will give the unmarked quest to find a bloatfly gland as part of a field trip. Passing a Charisma check, the Sole Survivor may ask her for caps as compensation for doing this side-quest.

Effects of player's actions

  • Duff will become depressed if Scara is recruited away from the Science! Center by the Sole Survivor for the Brotherhood of Steel during the quest Liberty Reprimed.



Doctor Duff appears only in Fallout 4.


  1. Duff: "Hi there! Are you here for today's free biology lesson?"
    The Sole Survivor: "Biology lesson?"
    Duff: "That's right. Usually the kids from the schoolhouse are the first to drop by, but I don't see why I can't start the lesson with you."
    The Sole Survivor: "Sure. Sounds fun."
    Duff: "Yes! Love that enthusiasm. Now we all talk about radiation like it's a single thing, but it's actually a term referring to dozens of different ionizing rays. You have X-Rays, Beta Rays, Gamma Rays... But which one are we most worried about? The one most associated with the big, old bombs 200 years ago?"
    The Sole Survivor: "Gamma rays?"
    Duff: "That's right! Now. Gamma rays are bad. Really bad. If your body absorbs too much of that kind of radiation, you'll suffer from fatigue, anemia, even death. But some life forms have been living with Gamma radiation exposure for two centuries now, and they've adapted. Neat, huh?"
  2. Duff: "Professor! I have a new theory how the Institute makes the synths."
    Scara: "Oh no. We banned talking about this, remember? After last time? The shouting? Me sleeping on the cold floor of the lab for three nights?"
    Duff: "That was your choice..."
    Scara: "And seriously... growing synths from the ground using recombinant plant nuclei? I mean, how could they even..."
    Duff: "Ah ha! You do want to talk about it!"
    Scara: "Uh... Oh look! We have a visitor! Doctor Duff, dear, if you could bother them while I walk away from this conversation..."
    (Duff's and Scara's dialogue)
  3. Duff: "You sure you won't help in my next experiment, Professor?"
    Scara: "Which one? You always do too many at once. How am I expected to keep track of all of them?"
    Duff: "I like to organize them by colors! If the compounds are mostly green, it's a green experiment. Mostly blue? Blue experiment."
    Scara: "Dare I ask which color of experiment you want help on?"
    Duff: "Magenta."
    (Duff's and Scara's dialogue)
  4. Scara: "Duff, if I've told you once, I've told you a thousand times... stop rearranging my work space. You're driving me crazy."
    Duff: "Aww. I was trying to surprise you by cleaning it up. I thought you'd be happy."
    Scara: "Sigh... I'm not mad at you, just frustrated. It might look like a mess, but I have a specific way of organizing everything that I own."
    Duff: "Oh. Then I'm guessing you won't be happy with how I rearranged our bedroom. Sorry, Professor!"
    (Duff's and Scara's dialogue)
  5. Duff: "Sorry to let you down, but I'm afraid I'm not in the mood to teach biology lessons today."
    (Duff's dialogue)
  6. Duff: "Oh... it's you. If you brought any Bloatfly Glands, why don't you bring them back later. I'm not in the mood to deal with it right now."
    The Sole Survivor: "If something's wrong, maybe I can help."
    Duff: "It's my colleague, Professor Scara. Her normal field expeditions never last more than a few days, but it's been over a week now. I'm afraid something terrible has happened to her."
    Cait: "Gone for a week? Got bad news for you, love... either she eloped or she's dead."
    Codsworth: "Oh dear. I hope she's all right."
    Curie: "We should help find her."
    Danse: "That doesn't bode well. She could be in trouble."
    Hancock: "Yeah, that sounds about right."
    Robert MacCready: "Yyyeah... you might want to start looking for someone else to bunk with."
    Piper Wright: "Gone for a week. Blue, she could be in real trouble."
    Preston Garvey: "That doesn't sound good. We'd better go find her."
    Strong: "Then human was weak."
    Nick Valentine: "Chance of survival after a week out there ain't that great for someone not used to roughing it."
    X6-88: "That seems likely."
    (Duff's, Cait's, Codsworth's, Curie's, Danse's, John Hancock's, Robert MacCready's, Piper Wright's, Preston Garvey's, Strong's, Nick Valentine's and X6-88's dialogue)
  7. The Sole Survivor: "Don't worry, I'll find her."
    Duff: "Oh! That would be wonderful. The last place Professor Scara said she was going is the General Atomics Galleria. I'll mark it on your mapping device there. Look, if you find her, could you tell her to come home?"
    (Duff's dialogue)
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