The first area of the sewer is patrolled by Talon Company mercs, the entry room contains two if it is entered from Dupont Circle. There is a grenade bouquet in the descending stairwell of the aforementioned room. With a high enough Explosives skill it can be disarmed, although it can be walked around. Proceeding further into the sewer, a battle between two more Talon Company mercs and two super mutants may be encountered to the west, one of which has a minigun. The cul-de-sac from which the super mutants attack contains a number of medical supplies and a ham radio.
To the east is a dead-end maintenance room that holds a number of parts, as well as a chamber containing waste barrels. The chamber is filled by a cloud of flammable gas, which may be ignited with an energy or flaming weapon, or by firing a conventional weapon while inside the cloud.
Beyond the toxic waste is a super mutant, armed with a heavy weapon, and a fallen Mister Gutsy (or sentry bot at higher levels) near a super mutant corpse, alternatively there may be two dead super mutants and a Mister Gutsy or sentry bot waiting. Moving uphill from here leads to a dead end, while a maintenance door leads to the hospital's boiler room.
The boiler room is full of super mutants. From here there is a door to the hospital, as well as spare parts and number of medical devices.
Once cleared of enemies, the mattress on the ground (not the ruined bed) at the far end of the tunnel can be used to catch some sleep.
South of the main sewer junction is a utility room, and in the back of it there is a copy of Dean's Electronics on the shelf.
The dry sewer appears only in Fallout 3.