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Diseases and viruses are various conditions distinct from mutations.


Diseases and viruses have played a pivotal role in shaping the world. Pre-War, various diseases and viruses were weaponized for use in biological warfare. New virions would be created in labs to gain the edge in countering offenses on frontlines.[1]

New Plague[]

Main article: New Plague

The New Plague is a disease that arose in the 2050s within the United States,[2] with symptoms including profuse sweating, unexplained contusions and swelling, and eventually terminating in massive external hemorrhaging.[3] In 2055, West Tek started to develop a cure for the plague, establishing the West Tek Research Facility. West-Tek was ultimately unable to develop a cure, despite their close ties to the federal government and their work in viral research through the Pan-Immunity Virion, and subsequent FEV, projects. Control of the West Tek Research Facility was handed over to the military in 2071.[2]

Forced Evolutionary Virus[]

Started from the Pan-Immunity Virion project, a preventative measure against Chinese use of biological weapons,[4] the Forced Evolutionary Virus was a powerful pathogen, capable of mutating any organism is came in contact with. It was utilized by the Master to create super mutants in New California from 2103 to 2162, finally being discovered and stopped by the Vault Dweller.[5] Other groups, such as the Enclave and the Institute, would also utilize FEV to accomplish their goals.[6][7][8]

In-game diseases[]

Name Game
Forced Evolutionary Virus
(Curling-13, Modified FEV, PIV)
All to date[9][10]
Troglodyte Degeneration Contagion Fallout 3: The Pitt
Parasites Fallout 4
Fallout 76
Mole rat disease Fallout 4
Insomnia Fallout 4
Lethargy Fallout 4
Fatigue Fallout 4
Weakness Fallout 4
Infection Fallout 4
Scorched Plague Fallout 76
The Blight Fallout 76
Blood worms Fallout 76
Bone worms Fallout 76
Buzz brain Fallout 76
Dysentery Fallout 76[11]
Fever claw Fallout 76
Flap limb Fallout 76
Glowing pustules Fallout 76
Heat flashes Fallout 76
Jelly fingers Fallout 76
Needle spine Fallout 76
Rad worms Fallout 76
Rattle hands Fallout 76
Shell shock Fallout 76
Sludge lung Fallout 76
Snot ear Fallout 76
Swamp gas Fallout 76
Swamp itch Fallout 76
Weeping sores Fallout 76
The Woopsies Fallout 76

Mentioned-only diseases[]

Name Game Ref
Anthrax Fallout 2 -
Beauveria mordicana New Vegas [12]
Black lung Fallout 76 [11]
Black Plague Fallout 2 -
Brain fever Fallout 2 [13]
Cancer Fallout 2
Fallout 3
New Vegas
Fallout 4
Fallout 76
Chicken Pox Fallout 2 [14]
Cholera Fallout 3
Fallout 4
Common cold New Vegas [17]
Cystic fibrosis Fallout 76 [11]
Diabetes Fallout 76 [11]
Dysentery Fallout 76 [18][11]
Ebola Fallout
Fallout 2
Gonorrhea Fallout (TV series) [19]
Influenza New Vegas
Fallout 4
Fallout 76
Fish poisoning Fallout 3 [21]
Gamma Cyclotronic Virus Fallout -
Hantavirus Fallout 2 -
Lyme disease Fallout 76 [22]
Lymphoma Fallout 76 [23]
New Plague Fallout
Fallout 3
Fallout 76
Parkinson's disease Fallout 76 [24]
Phase Shifting Virus Fallout -
Pneumonia Fallout 2
New Vegas
Red-lung Fallout 3 [21]
REPCONN Shakes New Vegas -
Rabies Fallout 4
Fallout 76
Rickets Fallout 3
New Vegas
Scorched Plague Fallout 76 -
Scurvy Fallout 76 [11]
Sepsis New Vegas [27]
Smallpox Fallout 2 -
Syphilis Fallout 2
Fallout 3
Fallout 4
Tetanus Fallout 3
New Vegas
Fallout 4
Tuberculosis New Vegas [31]
Vault depressive syndrome Fallout 3 -


In Vault 101, students were given a reading assignment from the Big Book of Science on how to combat airborne bacteria.[32]


  1. FEV research
  2. 2.0 2.1 2.2 The Vault Dweller: "{112}{}{Tell me about this installation.}"
    ZAX 1.2: "{117}{}{This installation was established in 2055 as a biological research facility for experimental cures of the New Plague. However, in 2071, this facility was placed under United States military command.}"
    ZAX 1.2: "{118}{}{Research into possible cures for the New Plague created the Forced Evolution Virus, which was further developed in an attempt to create a transmittable genetic-engineering virus -- in effect, infectious evolution.}"
  3. Disaster relief outpost terminal entries; terminal, Know the Signs!
  4. FEV research; 2073
  5. Events of Fallout
  6. Modified FEV
  7. Whitespring surveillance recordings; 8.5.4
  8. Scorched Plague
  9. Modified FEV
  10. Whitespring surveillance recordings; 8.5.4
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Pioneer Scout camp terminal entries; Pioneer badge exam terminal, TEST EXAM, Medic
  12. Vault 22 terminal entries; terminal, Species 3
  13. Valerie: "{280}{}{Don't you start. I'm glad Mom isn't here to hear this.}"
    Vic: "{282}{}{What? What happened to your mother?}"
    Valerie: "{284}{}{Brain fever. Caught it out on the wastes. Probably looking for YOU.}"
    Vic: "{286}{}{Oh. I... uh... I'm sorry, Val.}"
    (Valerie's dialogue)
  14. 14.0 14.1 The Chosen One: "{113}{}{Like what?}"
    Dave: "116}{}{I was born two months premature. When I was one, I was dropped on the porch. When I was two, I had pneumonia. When I was three, I got the chicken pox. When I was four, I fell down the stairs and broke six ribs. When I was five, my uncle was decapitated by a watermelon. When I was six, my parents hit me in the head with a shovel. When I was seven, I lost my right index finger to my pet rat.}"
    (Dave's dialogue)
  15. Tenpenny Tower terminal entries; exploration database, Places, Blue Destiny Brothel
  16. Weston water treatment plant terminal entries; Grounds terminal, Memo: Weston Media Event
  17. 17.0 17.1 The Courier: "What kinds of illnesses and injuries?"
    Arcade Gannon: "Cuts, lacerations, broken bones. Infections resulting from all of the above. Common cold, influenza. Take your pick. There are plenty of ways to die out here, and most of them, surprisingly, don't have anything to do with war. Just common human fragility."
    (Arcade Gannon's dialogue)
  18. Pioneer Scout camp terminal entries; Pioneer badge exam terminal, Tadpole Exams, Cook
  19. Sebastian Leslie: "I'm telling you, radicalism is sweeping through Hollywood like a bad case of the clap."
    Fallout TV series, Season 1, Episode 4: "The Ghouls"
  20. Greater Mass blood clinic terminal entries; Exam room terminal, 10905-2508
  21. 21.0 21.1 21.2 Rivet City terminal entries; Rivet City Clinic patient data system, Regional Health Hazards
  22. Settler: "Damn blood-suckers! I hope nobody gets Lyme's disease."
    (Settlers' dialogue)
  23. Veterinary diagnosis sheet
  24. Niraj's confession
  25. Vault 22 terminal entries; Common Areas Clinic terminal, Case 162
  26. The Lone Wanderer: "That sounds like it's pretty useful fungus."
    Lucy: "It is, especially for dealing with the low-level radiation we all get from the water. The fungus just soaks it right up. But it doesn't help the rickets that keeps hitting younger Lamplighters. Believe it or not, I can make a treatment for that from extract of Buffout. Actually, if you can talk MacCready into it, I'd be glad to trade some fungus for Buffout. But he'd have to say it was okay."
    Lucy's dialogue
  27. 27.0 27.1 The Courier: "Oh come on, that stuff's fun!"
    Courier's brain: "Fun? Fun?! Is tetanus fun? Hmm? Is rickets? What about sepsis, enjoy that do we? The things you do with our body are suicidally dangerous, and if you could silence your glandular impulses, you would hear me screaming at you!"
    (Courier's brain's dialogue)
  28. Curie: "Oh, the ship is covered in rust. Have you had your tetanus shot?"
    (Curie's dialogue)
  29. The Courier: "Why are you such a dick?"
    Courier's brain: "Well, that's a fine how-do-you-do! Me! A, quote, dick, unquote. As if I'm the one responsible for the way you carry on, gadding about the Wastes. I'm not the one that makes us clamber around tetanus-infested ancient Vaults or go charging off to New Vegas on missions of ill-conceived revenge! And have we forgotten who got us shot in the head and buried in a shallow grave? Hmm? Do you think I enjoyed that little moment?"
    The Courier: "Oh come on, that stuff's fun!"
    Courier's brain: "Fun? Fun?! Is tetanus fun? Hmm? Is rickets? What about sepsis, enjoy that do we? The things you do with our body are suicidally dangerous, and if you could silence your glandular impulses, you would hear me screaming at you!"
    (Courier's brain's dialogue)
  30. The Courier: "Okay, fix me. Here's 100 caps."
    Ada Straus: "All right, I'll just get my scalpel here, and... ugh. Did I leave that sitting outside? Well, you know what? Free tetanus shot!"
    (Ada Straus' dialogue)
  31. Stone Bones cave terminal entries; terminal, Year 2096 I.
  32. Vtrim02.dds texture file chalkboard