Jack and Diane are advisers to Papa Khan. The pair run a drug-trafficking ring and supply the Great Khans with drugs. Jack makes the drugs, and Diane handles the business. According to Regis, Jack and Diane have been close since childhood, and it is implied that they have an emotional attachment to each other, or at least Jack does, since he becomes upset when told that the Legion would put Diane into slavery.
If the player character has a negative reputation with the Khans, Diane will not interact with them, instead saying, "Get away from me, you lunatic!"
If the player character has killed Motor-Runner or the fiends Driver Nephi, Cook-Cook or Violet, Diane will express frustration that somebody took out some of their biggest clients, apparently unaware that it was the player character.
After completing the quest Aba Daba Honeymoon, Diane will teach Courier a special unarmed perk called Khan Trick.
If the Courier can pass a 50 Barter check, they can convince Diane that it would make more sense to try to sell helpful chems to the surrounding settlements; with a success, she will agree and the player character will get 50 XP and positive Karma.
"With Anders out of commission for so long, we're shorthanded on runners, and some backlogs have piled up. We've got an associate in the Crimson Caravan Trading Company who distributes for us in Outer Vegas. He's been after us for a new shipment. You up for something challenging? I've got a shipment of Jet and Psycho that needs to be delivered to Motor Runner at Vault 3."