Deathclaws spawn in specific places in the Mojave Wasteland, building nests and laying eggs. These eggs can be used to create consumables such as wasteland omelettes. When describing the NCR Rangers to the Courier, Stepinac states that to become a ranger, you have to prove that you can be "quieter than a shadow and more ferocious than a deathclaw."
In Quarry Junction, northwest of Sloan, there are two larger deathclaws called the "deathclaw alpha male" and the "deathclaw mother" as well as a number of smaller baby deathclaws and three to four eggs.Chomps Lewis will warn the Courier not to traverse father than Sloan due to the danger of the deathclws in the quarry. If the Courier kills only the alpha male or mother, Chomps will comment that as long as the mother or alpha is still alive, the pack will remain, and both need to be killed.
Found along the Courier's Mile and among the ruins of Hopeville and level with the Courier. Their statistics are varied according to the Courier's level, making them very dangerous if the Courier is near the level cap. Irradiated deathclaws deal radiation damage. Unlike other variants, irradiated deathclaws have zero Damage Threshold.
Rawr: In the Lonesome Road add-on, there is a unique deathclaw named Rawr, found in a cave in the Divide canyon. When killed, it drops its talon, which can be crafted at a workbench into a unique deathclaw gauntlet called the Fist of Rawr (or Fist of the North Rawr with the Wild Wasteland trait).
↑Courier: "Where can I find a Deathclaw egg?" Jas Wilkins: "The quarry just north of here is full of Deathclaws, so there's bound to be an egg or two in there somewhere. Of course, a Deathclaw egg from anywhere will do. According to my Aunt Rose, those things have a ridiculously long shelf life." (Jas Wilkins' dialogue)
↑Courier: "Tell me about the Rangers." Stepinac: "We're part scout, part commando, part sheriff. The training is brutal, and I'd say eight out of ten recruits washes out before the end. Before you get your Ranger badge, you've got to prove you can be quieter than a shadow and more ferocious than a Deathclaw." (Stepinac's dialogue)
↑Courier: "I could take care of your Deathclaw problem." Chomps Lewis: "Have you even seen a Deathclaw? They're taller than a man and far, far stronger and faster. And, there's a whole pack of them out there. You'd have to be the meanest, toughest, roughest bastard in the wasteland to have any chance against them, and I don't think that's you. You'd need to take out the pack leaders - the Mother Deathclaw and the Deathclaw Alpha Male. Kill 'em, and the pack will scatter. Pretty tough job." (Chomps Lewis' dialogue)
↑Courier: "Have you had problems with Deathclaws before?" Chomps Lewis: "We'd see them occasionally, but they didn't seem too keen on getting too close to the quarry. Not sure if it was the noise or all the workers. I can't believe that an entire pack moved into the quarry. I thought that kind of bad luck only happened in New Vegas." (Chomps Lewis' dialogue)
↑Courier: "I killed the Mother Deathclaw." Chomps Lewis: "You... you did? That's pretty amazing - I figured you'd need artillery to take her out. I hate to say it, but as long as the Alpha Male is still alive, that pack isn't going anywhere, even with the Deathclaw Mother out of the picture." (Chomps Lewis' dialogue)
↑Courier: "I killed the Deathclaw Alpha Male." Chomps Lewis: "You... you did? That's pretty amazing - I figured you'd need artillery to take him out. I hate to say it, but as long as the Deathclaw Mother is still alive, that pack isn't going anywhere. She'll take another mate and keep laying eggs." (Chomps Lewis' dialogue)