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Darling sister's lab is a location in the Forest region of Appalachia. It can be found southwest of Groves family cabin and north of Tyler County Fairgrounds.


Overlooking Route 81 from the rocky ridge, this collection of shacks was once the site of a drug operation.[1]


There are four main shacks here as well as a metal trailer with a chemistry station inside. Various pieces of science equipment for making chems can be found throughout the location while the brightly-lit shack contains a locked safe (Picklock 3). The northeastern shack has a tinker's workbench inside.

Notable loot

  • Potential Vault-Tec bobblehead - On the roof of the "welkcomIn-game spelling" metal caravan trailer, by the gramophone and banjo.
  • Potential magazine - In the cabin with a weathervane on top, behind an empty picture frame on the ground near a mattress.
  • Potential recipe - On a barrel behind a colored archery target.


Darling sister's lab appears only in Fallout 76.



  1. Fallout 76 Vault Dweller's Survival Guide p.296: "18. DARLING SISTER'S LAB
    A collection of small, ramshackle structures atop the long rock ridge to the east of Route 81. The Darling Sisters seem to have been chem... connoisseurs."
    (Fallout 76 Vault Dweller's Survival Guide Atlas of Appalachia)