During Wilson and Darcy's investigation, the two discovered a conspiracy which originated from the government itself, leading Wilson to quit his job to continue his investigations. As part of the investigations, Wilson looked into local Vault-Tec University student Shelby O'Rourke who he encountered while she was setting up a thesis study into local cryptids. Although an initial background check revealed nothing of suspicion, Wilson noted her determination to find proof as a potential asset in the future, given the other investigations he was undertaking.
Both Wilson and Darcy survived the bombs and the event led to doors opening which were previously shut. Before the two could finish their investigations, Scott Darcy turned up dead under suspicious circumstances. This led Wilson to lock down his terminal and go into hiding until the time was right for him to emerge with his findings.
Curtis Wilson is mentioned only in Fallout 76.