Curtis was born on June 14, 2052. He held a 3.8 GPA during the 2077-78 school year. He decided to help Professor Stuart Campbell with his secret experiments in exchange for money. While working with Professor Campbell, Curtis grew close with his fellow student Leslie Mathews. By the time of the Great War, Curtis was in the university's underground lab when the bombs fell. He and the staffers continued Professor Campbell's research until their supplies ran out. After deciding to abandon the laboratory, Curtis asked Leslie to marry him.
Curtis Marsh is mentioned only in Fallout 4.