Crescent Canyon east is the eastern side of a large crescent-moon-shaped canyon connecting with Crescent Canyon west, forming a natural barrier along the southern end of the map. It is populated by golden geckos and is strewn with radioactive waste barrels. A train (that was most likely carrying these radioactive waste barrels) can be found with half of its cars at the bottom of the canyon.
The canyon is irradiated and the Courier may require anti-radiation items and apparel in order to explore it. At the east end of the canyon, there is a hollowed-out rock at the bottom of the hill to the right.
- On top of the canyon, right where the train bridge has collapsed, the inaccessible side is noticeably a great distance above the other side. It is unknown how trains could get up such a steep slope.
- On the north side of the railroad, after the train car, the road becomes a normal street/highway with no evidence of railroad tracks continuing on the other side or to have fallen down below.
Crescent Canyon east appears only in Fallout: New Vegas.