Crescent Canyon east is the eastern side of a large crescent-moon-shaped canyon connecting with Crescent Canyon west, forming a natural barrier along the southern end of the map. It is populated by golden geckos and is strewn with radioactive waste barrels. A train hangs over the canyon from the roadway above, with some cars resting at the bottom of the canyon. The canyon is irradiated, resulting in 4 rads/second. At the east end of the canyon, there is a hollowed-out rock at the bottom of the hill to the right.
There is an advanced radiation suit roughly half-way through the canyon, near an overturned truck in a marked case.
On the north side of the railroad, after the train car, the road becomes a normal street with no railroad tracks continuing on the other side or found in the canyon below.
Crescent Canyon east appears only in Fallout: New Vegas.