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Clayton Holdren (username Holdren.C)[1] is a member of the Institute, working as head of the BioScience division in 2287.


Doctor Clayton Holdren is the head of BioScience in the Institute, working on botany, genetics, and medicine. He has recently begun working on synthetic animals, namely gorillas. Currently, they are a pet project, but Clayton hopes to use them as proof that the potential is endless.[2] He has a great deal of confidence in his team, stating that Doctor Volkert provides better medical care than anywhere else in the Commonwealth.[3] When reprimanding, he can be patronizing, but in a student-teacher way.

In dialogue with Isaac, he mentions how he prefers not to think about the suffering that the Warwick family may have gone through. However, regarding science, he is constantly cautiously optimistic.

Interactions with the player character

Interactions overview

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This character starts quests.



In the trash can of his bathroom is a copy of the Join the Railroad holotape. A copy of Astoundingly Awesome Tales can also be found on the balcony of his room.


Clayton Holdren appears only in Fallout 4.


PCPC Playstation 4Playstation 4 When talked to, Clayton may be seen holding an invisible clipboard.[verified]


  1. The Institute terminal entries; BioScience terminal (wall)
  2. The Sole Survivor: "I look forward to learning more about it."
    Clayton Holdren: "In that case, let me give you a brief overview of what we do here. As the name implies, the BioScience division specializes in fields of study such as botany, genetics and medicine. Our most important directive is to ensure the health and well-being of everyone in the Institute. To that end, we cultivate highly specialized breeds of flora for use in food and medicine. We've even started to explore the idea of synthetic animal life. You probably saw the gorillas... they're really just a pet project at this point, but the potential is exciting nonetheless."
  3. The Sole Survivor: "You mentioned medical care. I might need that from time to time."
    Clayton Holdren: "In that case, you'll want to introduce yourself to Doctor Dean Volkert. He's our top biologist, and also serves as the Institute's resident physician. Doctor Volkert works in the infirmary. Just pay him a visit whenever you need to. You won't find better medical care anywhere else in the Commonwealth, I'll promise you that."
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