|For an overview of Nuka-Cola, see Nuka-Cola.|
For an overview of Nuka-Cherry, see Nuka-Cherry.
|The following is based on Fallout Tactics and is not canon.|
Nuka-Cola entered the beverage market in 2044, with the invention of the soft drink by John-Caleb Bradberton after two years of experimentation. It contained 120% of the recommended daily allowance of sugar, and took the United States market by storm, and within a year could be purchased nationwide. Its popularity rapidly increased and within several years it was the most popular beverage across the globe.
The unique taste of Nuka-Cola is the result of a combination of 17 fruit essences, balanced to enhance the classic cola flavor. Additives such as aspartame, phosphoric and citric acid, caramel color, caffeine, and potassium benzoate were added to carbonated water along with additional natural flavors, resulting in the product's formula. 
It was marketed as being fortified with vitamins, minerals and "health tonics." Ingredients were combined in just the right proportion, to the level that shortages of ingredients or changes to the recipe were noticed by consumers. Frequent consumption could cause addiction, which led to splitting headaches.
Cherry Nuka Cola is a variation of regular Nuka-Cola. After it was introduced, it turned out that nobody liked the taste. This resulted in a marketing disaster for the company, which quickly attempted to save the brand by introducing the Classic Nuka-Cola, tasting exactly like the original, but in a new bottle.
Cherry Nuka-Cola resembles the original Nuka-Cola bottle but the liquid inside is a bright red instead of being brown. Instead of having 17 fruity flavors this unpopular Nuka-Cola only had the one (cherry). It has no effects, and unlike its regular counterpart does not have a risk of Nuka-Cola addiction.
- Held by Hillary Eastwood, the mayor of Quincy.
- Sold by Gloria, a prostitute in Great Bend.
- In a pot during the mission at Buena Vista.
- In a refrigerator along with two yellow Nuka-Colas in Peoria.
Behind the scenes
- The name of the Nuka-Cola creator, John-Caleb Bradberton, is an amalgamation of the inventors of Coca-Cola (John Pemberton) and Pepsi-Cola (Caleb Bradham).
- The story of its introduction, rejection, and replacement by Classic Nuka-Cola mimics that of New Coke. While New Coke received generally positive reactions in initial taste tests, the iconic status of the old formula produced a strong backlash reaction that pressured executives into changing it back.