Calmex is a pre-War light tranquilizer. While it doesn't work as a pain killer when administered, it carries a high enough dosage to cause a boost to some survival senses that are ordinarily dulled by reasoning.
A variant of Calmex produced by Maddox in the Nuka-Town market from bloodworm meat. While it is identical in appearance to standard Calmex, it boosts the user's Luck by 3 in addition to its usual effects.
Due to how gameplay works in Fallout: The Board Game, Calmex has different effects and usage than in other games. Rather than boosting multiple SPECIAL stats and sneak attack damage, Calmex can be used during a fight or test to automatically gain either one point of agility or perception. After this, the player character must pass an endurance check or gain the addicted trait.