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Burke may refer to:
- Mister Burke, Allistair Tenpenny's right-hand man in Fallout 3.
- Burke (Fallout: New Vegas), a location surveyor for the New California Republic Army, mentioned in Fallout: New Vegas.
- Senator Burk, a senator in the United States Senate before the Great War, mentioned in Fallout 76.
- Burke (Fallout Tactics), a member of General Simon Barnaky's Brimstone Squad in Fallout Tactics.
- Burk, the leader of the Scorpion's Bite and a member of the Hounds of Hecate raider gang in Van Buren.
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