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You used the chem Buffout once too often and now your body is craving for more... and more... and more... well done! You got yourself addicted.

Buffout addiction is a form of addiction which can occur in Fallout, Fallout 2, Fallout 3, Fallout: New Vegas, Fallout 4, Fallout 76 and Fallout Tactics.

Fallout, Fallout 2, Fallout Tactics

You've got the shakes.

Buffout has a 25% chance to cause addiction. It lasts for a week, beginning 48 hours after consumption. When addicted, one suffers a 2 point penalty to Strength and Endurance and a 3 point penalty to Agility.

Fallout 3, Fallout: New Vegas

Buffout has a 10% chance to cause addiction. The penalties of being addicted have been significantly lowered, as being addicted only causes a 1 point penalty to Strength and Endurance.

Fallout 4, Fallout 76

Buffout, Buffjet, and Bufftats respectively have 25%, 35%, and 35% chance to cause addiction. When addicted, the player character suffers a 1 point penalty to Strength and Endurance. The addiction can be cured by visiting a doctor, taking addictol, eating a radscorpion egg omelette or drinking a refreshing beverage.

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