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Fallout 3Buffout
Fallout: New VegasBuffout
Fallout 4Buffout
Fallout 76Buffout
Fallout: The Board GameBuffout

Buffout is a drug appearing across the Fallout series.


Fo4 Buffout Label

Buffout is a brand of highly advanced steroids that increase strength, reflexes, and endurance. Although highly addictive,[1] it was a popular choice among pre-War athletes.[2] Their clandestine - and illicit - use of the drug made its use by amateurs popular and widespread.[Non-game 1][2] With it, they could run longer and work out harder without the burden of "unnecessary" training.[3] The popularity of the drug resulted in a number of hybridized variants, including Bufftats (mixed with Mentats) and Psychobuff (military modification, combined with Psycho).[4] It was sold before the war in bottles of 50 tablets each.[5]

Its popularity persists well after the nuclear holocaust, due to its properties. The increase in strength allows a wastelander to punch through several wooden boards with ease and pummel opponents into submission.[6] As such, it's typically banned in places like Vault City[7] or entertainment venues. For example, casino and bar patrons in New Reno were banned from indulging in Buffout.[8]

Despite being an addictive steroid, with proper use, Buffout can easily treat rickets in children.[9]


Original Buffout[]

Chem Buffout

"The Original" drug increases strength, reflexes, and raises the maximum health, with the disadvantage of being highly addictive.


Gameplay article: Fallout 4

Introduced in Fallout 4, this variant is made in a chemistry station and is a combination of Buffout and Jet. Slows time for 15 seconds in addition to the usual Buffout effects.


Gameplay articles: Fallout 4, Fallout 76

Another Buffout variant introduced in Fallout 4. Made in a chemistry station using Psycho and Buffout. Grants +25% damage dealt, +3 Strength, and +3 Endurance.


Gameplay articles: Fallout 4, Fallout 76

Another Buffout variant introduced in Fallout 4, this variant is made in a chemistry station using Buffout and Mentats. Grants +3 Strength, +3 Endurance, +65 HP, and +3 Perception.

Behind the scenes[]

Eric states that Buffout will cause the player character's mind to suffer when taken, but this functionality is not actually present in the game.[10]



  1. Fallout Demo, Fallout and Fallout 2 item description: "{8700}{}{Buffout}"
    "{8701}{}{Highly advanced steroids. While in effect, they increase strength and reflexes. Very addictive.}"
    (PRO ITEM.MSG (demo), PRO ITEM.MSG (Fallout), PRO ITEM.MSG (Fallout 2))
  2. 2.0 2.1 Fallout 4 loading screen hints: "Buffout is a powerful steroid that gained popularity with athletes before the Great War. It grants temporary bonuses to Strength, Endurance and maximum Health."
  3. Rose's Raider Radio: "Take yourself some Buffout. Run longer, and hit harder! You'll be a star athlete in no time, no training required!"
  4. Drug variants in Fallout 4 and Fallout 76.
  5. Texture in Fallout 4
  6. Goodneighbor terminals; Fred Allen's Terminal, Chem Diary: Buffout: "Experiment One: Punch through a board.
    Results: Oh yeah. That was easy.
    Experiment Two: Punch through TEN boards.
    Results: I'm invincible! This is like, some comic-book level strength.
    Experiment Three: Punch through STEEL boards, man!
    Results: Typing with my left hand. Gotta cook some Stimpaks."
  7. Vault City gate guard: "{187}{}{All right. Before you go in, we have to search your belongings first.}"
    The Chosen One: "{189}{}{What for?}"
    Vault-City gate guard: "{202}{}{Sometimes Outworlders try to smuggle alcohol or addictive drugs into Vault City: Buffout, Jet, Psycho, Mentats...that sort of thing.}"
  8. Shark Club, Desperado, Maltese Falcon, and Salvatore's bartenders: "{219}{}{We don't let customers take Buffout in here, pal.}"
  9. The Lone Wanderer: "That sounds like it's pretty useful fungus."
    Lucy: "It is, especially for dealing with the low-level radiation we all get from the water. The fungus just soaks it right up. But it doesn't help the rickets that keeps hitting younger Lamplighters. Believe it or not, I can make a treatment for that from extract of Buffout. Actually, if you can talk MacCready into it, I'd be glad to trade some fungus for Buffout. But he'd have to say it was okay."
    Lucy's dialogue
  10. Eric: "{170}{}{These pills are called buffouts. They'll increase your strength, but your mind will suffer for a little bit. Don't take too many or you might get hooked. Good luck with the fist!}"