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Boston was first settled in the early 1630s by European colonists. Many of the important historical events of the American Revolution such as the Boston Massacre, the Boston Tea Party, Paul Revere's midnight ride, the battles of Lexington and Concord and Bunker Hill, and many others occurred in or near Boston.
The Institute was a prestigious university located in Boston. It seemed to continue well into the 21st century, Robert House being a student in his younger years. Following the war, the Institute managed to survive and even thrive. The scientific community inhabiting the university has created technologies vastly superior to anything else seen in the wasteland. Androids, specifically, are one of the creations to come out of the Institute.
It is unknown whether or not Boston was hit directly during the Great War. However, a mushroom cloud can be seen near Vault 111. Its status as a major city would suggest that it was attacked in some form.
Post-war, The Commonwealth has been described by Dr. Zimmer as "a war-ravaged quagmire of violence and despair". It is likely that Boston, being within the region, is the same.
The city centre comprises of several tall skyscrapers, one of which is the Institute. Many pre-War buildings, monuments and landmarks are still standing, but have worn with time, with some being renovated with scavenged parts, and having a very ramshackle appearance, suggesting that central Boston may have partly defended themselves against a nuclear attack in some way, as did Robert House with Las Vegas. In the outer areas outside of the city centre are rolling barren plains, wastelands, and suburbs.
Boston appears only in Fallout 4.