Ashes is a house cat owned by Erin Combes in Vault 81. The first time the Sole Survivor enters Vault 81, Ashes runs past them out of the vault. When Erin Combes is talked to, the quest Here Kitty, Kitty starts. Ashes runs outside of the vault to the northeast of the nearby Chestnut Hillock Reservoir, near the dock. Upon completion of Here Kitty, Kitty, Ashes will usually follow Erin Combes.
The Sole Survivor can give chase immediately, and catch Ashes quickly. The Sole Survivor will still say "Go home, Ashes; Erin misses you!" despite never having met Erin or been told about Ashes. The quest will start upon interacting with Ashes.
If Ashes was caught before talking to Erin, he will be in her room. If the Sole Survivor is on Austin's tour, she will not acknowledge Ashes' presence or complete the quest until the Vault 81 Tour is over.
If the Sole Survivor stays in the entrance area for too long, they may overhear some vault dwellers discussing the disappearance of Ashes, before the cat even escapes.
After doing 'Here Kitty, Kitty' Ashes will follow Erin around all the time; to her bed, to her school, etc.
If the Sole Survivor accepts the quest but does not find Ashes, Ashes will turn up inside the Institute at the reactor during the quest The Nuclear Option. He can then be sent home as normal.
Cait and X6-88 like it if the Sole Survivor kills Ashes when he escapes Vault 81.