Appalachia is the general name given to post-apocalyptic West Virginia.
Located within the Eastern Commonwealth of the former United States, the region was spared most of the destruction and carnage of the Great War due to its relative isolation and lack of strategic targets, but much of the surviving human population nonetheless perished over the following years due to the Scorched Plague. In 2102, the residents of Vault 76 emerged into Appalachia after twenty-five years of isolation and began to reclaim the wilderness.
It serves as the game-world of Fallout 76.
In 2102, twenty-five years after the Great War, Appalachia consists of a vast, mostly intact swathe of the state of West Virginia, and becomes the focus of reconstruction efforts led by the residents of Vault 76.
While the predominately rural landscape is mostly unscathed, it is plagued by irradiated and mutated creatures. Of particular concern is the Scorched Plague, caused by a hazardous, mutagenic fungus indigenous to the vast caverns beneath Appalachia. Scorched plague is spread by scorchbeasts, which periodically breach the surface and terrorize the countryside.
In the aftermath of the Great War, a number of factions formed among the survivors, including continuations of pre-War groups like the Enclave and Free States, along with post-War organizations such as the Brotherhood of Steel, raiders and Responders. These groups were all wiped out prior to 2102 by the Scorched, though there are some remnants such as the Enclave's AI, MODUS.
Appalachia appears only in Fallout 76.