The main entrance of Andrew station is inside a half-collapsed building. The roof of the building can be accessed using makeshift stairs on the side. The station is inhabited by raiders which are led by Chancer. On the ground floor of the station is an automated turret.
Underground the station consists of a long network of tunnels, though most of these have become inaccessible. The tunnels lead both to Eddie Winter's hideout, which can only be accessed at the end of the Long Time Coming quest and to Chancer's quarters. There is another exit in Chancer's quarters that may be opened using the key in Eddie Winter's room.
Andrew Station can be accessed from a Master locked trapdoor behind the counter of Joe's Spuckies sandwich shop, just north of the South Boston Police Department and south of Mass Bay Medical Center. A key to the trapdoor can be found in the small theater room under the trapdoor.
Multiple crafting stations can be used at this location:
- Two weapons workbenches: One on the roof of the building, and another inside the subway station on an open space after a corridor defended by an automated turret.
- One armor workbench: On the roof of the building, next to the weapons workbench.
- Two cooking stations: On the ground floor, in eyesight of the stairs that go down the subway station, and another is located next to the second weapons workbench, inside the subway station.
- Two chemistry stations: On the ground floor, next to the cooking station. A second station can be found behind the door in the same room as Chancer is in. The door is to be unlocked by pressing the button on the wall behind the bar.
- Grognak the Barbarian Issue #2 - Outside of the main station entrance, on the top floor of a destroyed yellow house that is directly north of the main station entrance, it is recognizable by the crashed bus in the roof.
- One Vault-Tec lunchbox - Inside the bus which has crashed into the yellow house.
- One fusion core - Underneath the overpass right next to the lift south-southwest of the station.
- Two Stealth Boys - To the west of the station, in a trailer unlocked with the Wicked Shipping trailer key.
- Multiple Vault-Tec lunchboxes - One in the locked room where Chancer may be found, one in a room directly south after going down the second flight of stairs, one in the speakeasy area behind the locked security door which can be opened by pushing a button behind the bookshelf found at the rear of the counter, and several inside the crashed train cars.
- One Stealth Boy - Behind a Novice lock on the train level of the subway on the southwest side.
- A pair of boxing gloves - In a locker to the left of the lower entrance in the room, next to the ring that is located near Eddie Winter's room.
- Eddie's Peace - A unique pistol carried by Eddie Winter. It may not show up in his inventory but may be picked up off the ground. The pistol cannot be recovered before the final part of the Long Time Coming quest.
- To Claire - A holotape found on the cabinet beside the bed with a last pre-War message from Eddie.
- Joe's Spuckies basement key - At the end of Andrew Station tunnels, on a wooden shelf next to the ladder up to the shop. The key opens the trapdoor to Joe's Spuckies sandwich shop.
- Long Time Coming: Nick Valentine is still disturbed by memories he inherited from pre-War Nick and tells of an old gangster named Eddie Winter, who used to be one of the largest crime bosses in Boston. He needs the help of the Sole Survivor to make peace with his past.
- Raider Troubles: A group of settlers is struggling to defend themselves against a nearby group of raiders and asks the Sole Survivor for help.
- Diamond City's Most Wanted: A bounty board in the Diamond City market gives the Sole Survivor a target to handle in exchange for caps.
- To the Mattresses: The synth-hating L&L Gang is a major threat to the Railroad. Desdemona has a lead on them and asks the Sole Survivor to help neutralize their members.
- In the quest Long Time Coming, Nick will attempt to move through the station ahead of the player. This presents a problem since he will run straight into mines.
- The locked electric door containing the reward chest is connected to a button behind a bookshelf. Follow the door's copper wire to find the button.
Andrew station appears only in Fallout 4.