To survive against the Scorched Plague that spreads among the humans of Appalachia, the Responders attempted to create a vaccine years ago using the equipment in AVR Medical Center. The project was not successful at preventing their demise, but maybe Dr. Hudson left behind enough data to complete it and save the Vault 76 Dwellers from meeting a similar fate.
|Main quest: An Ounce of Prevention|
|Access the terminal at AVR Medical Center.|
|Collect a Type-T Fuse from the Charleston Trainyard.|
|Collect a blood sample from a Feral Ghoul.|
|Return to the AVR Medical Center and load the blood sample into the centrifuge.|
|Synthesize the vaccine using the terminal.|
|Enter the machine and inoculate yourself.|
|Reward: Legendary leather armor|
Scorched plague inoculation
Photo frame - The Responders
|Completed. Leads to Into the Fire|
- After completing Final Departure, the next stop is Charleston and the AVR Medical Center. Hudson's lab is located in the southwestern corner of the facility, in the basement (either drop down through the cafeteria floor or use the staircase by the street exit). Use the terminal to learn the story and that she almost completed her research. The automatic software set up by the doctor is set up to auto-create a vaccine from the DNA of feral ghouls.
- The player characters need to collect that and a type-T fuse. The fuse can be found in the Charleston Trainyard.
- Feral ghouls can be found all over Charleston, mostly in the eastern parts and around the Capitol Building.
- Once the player character has both ingredients, they just need to get back to the AVR Medical Center and Hudson's lab, place the replacement fuse in the fuse box under the stairs, put the blood sample in the centrifuge by the AVR medical terminal, analyze it, then use the Sympto-Matic to inoculate themselves. Claire Hudson's recording will play, directing them to the Fire Breathers of the Charleston Fire Department, leading to Into the Fire.
- As of patch 18.104.22.168, the type-T fuse is located in the Charleston Trainyard instead of Greg's Mine Supply.
- Previously, the quest required additional blood samples from wolves and mole rats. This was removed with patch 22.214.171.124.
- With the release of Wastelanders, this quest is mandatory to proceed with "The New Arrivals".
Behind the scenes
The title is a reference to the famous Benjamin Franklin axiom that "an ounce of prevention is worth a pound of cure," meaning that taking small steps to prevent a major problem is easier than dealing with the problem itself.
- patch 126.96.36.199, the map marker for the Type-T fuse may have focused on an underground tunnel instead of the item. The item could be found in an explosives crate in the eastern storage room of Greg's Mine Supply.[verified]
- As of the aforementioned patch, the fuse is found in the Charleston Trainyard instead.
- patch 22, the terminal used to operate the centrifuge would not analyze the blood samples and instead output the "Requires blood" error message.[verified]
- One way to fix this bug is to leave the server and go back to the main screen, then join Adventure Mode (public server) again. Now both quest goals "Install Type-T Fuse" and "Analyze Blood Sample" will appear again. After this, go to AVR Medical Center and install the Type-T fuse, then fast travel or otherwise leave the building and close the game. Reboot the game again and join Adventure Mode with both quest goals present. Go to AVR Medical Center and install the Type-T fuse once again, hit the terminal with "Analyze Blood Sample" and it should work.
- As of the aforementioned patch, this bug has been fixed.