Initial subjects showed signs of immediate atrophy and significant damage to musculature. Immense pain reported by several subjects; others were incapable of speech.
Subjects were nearly impossible to restrain physically, exhibiting a significant increase in strength in the brief period before death.
The Whitespring bunker terminal entries

Adrenal Reaction is a mutation in Fallout 76.


Positive effects
Increased weapon damage and health regeneration at low hit points.
Negative effects
Reduced maximum hit points (-50 HP).


  • Adrenal Reaction is essentially a global Bloodied affect to all weapons used.
  • Adrenal Reaction synergizes very well with the Bloodied modifier legendary weapons, as it effectively doubles the damage increase for any bloodied weapons.
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