Mrs. Able, along with Mr. Able, was one of the citizens of Sanctuary Hills that both secured a place in the Vault program and made it to Vault 111 before the nuclear devastation reached Massachusetts. She and her husband were among the last people to enter the vault, just as the bombs struck the vicinity of Boston.[1]
Along with the other cryogenically frozen occupants of Vault 111, she died from asphyxiation after the life support to the cryo pods was cut in 2227 by the Institute during Shaun's kidnapping.[2]