Face à l'absence d'informations pertinentes concernant la présence des super mutants dans Fallout 4, et suite aux débats ayant eu lieu au sein de la communauté francophone de Fallout quant à leurs origines, seules les informations validées seront affichées.
Les super mutants sont des créatures massives, musclées et naturellement immunisées contre les radiations et les maladies. En 2287, les habitants du Commonwealth peuvent, le plus souvent, rencontrer ces super mutants dans le centre de Boston et sa banlieue, mais également un partout dans les environs de la ville, ainsi qu'à Nuka-World et sur l'Île. La plupart des camps de super mutants peuvent être facilement identifiés via plusieurs éléments tels que des sacs de viande, des poutres en métal tordues dépassant du sol, des cages et des morceaux de chair, avec lesquels ils aiment décorer leurs bases ou leurs campements.
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La présence des super mutants sur l'Île s'explique par le fait qu'un groupe de super mutants a probablement dû voyager jusque là avant d'installer plusieurs campements dans les endroits laissés à l'abandon tels qu'à Vim! Pop Factory, National Park HQ et Aldersea Day Spa. Il en va de même concernant leur présence à Nuka-World où l'on peut parfois trouver de petits groupes errants dans les plaines ou au pied des murs entourant le parc d'attractions.
This is the most common and weakest variety of super mutant. They usually carry a pipe weapon or a board and drop minor and low-tech loot on death. They can usually be taken down with minimal effort. They can often be found among more powerful varieties of super mutant such as a skirmisher.
A super mutant that will run at its enemy with a beeping mini nuke in its arm. It will then detonate itself while in close proximity, killing its enemy and itself in a fiery, nuclear explosion. Shooting the mini nuke in the suicider's hand or targeting the right arm in V.A.T.S. will cause the mutant to explode prematurely, killing it instantly. As a result, shooting the bomb from afar is one of the most effective ways to dispatch them, and potentially other nearby enemies as well. If one is desperate to kill a suicider and the only weapon types available are unarmed and/or melee, the player may either sneak attack it, or run to it, strike it, step back a bit and repeat until it's dead (though the latter is not advised as one missed attack will allow the suicider to detonate the mini nuke, and accidentally hitting the mini nuke with either type of attack will detonate it). The suicider can be detected before it is seen by listening for the beeping of its mini nuke. If the suicider is killed without detonating the payload, which can be done with a headshot or body shot, a mini nuke can be looted from its corpse; otherwise, only nuclear material will be found on its remains.
Utilizing the Blitz perk, it is possible to kill the suicider in V.A.T.S. with a melee weapon before it explodes, even if it takes several hits.
Super mutant skirmishers are significantly tougher than regular super mutants, taking more damage and usually carrying more powerful weapons. Skirmishers will appear more frequently once the Sole Survivor reaches level 10.
A force to be reckoned with, super mutant masters have an extremely high Hit Point pool and superior Damage Resistance compared to their weaker brethren. They are generally equipped with heavy weapons such as the missile launcher or minigun. They can be generally found in locations with a large mutant concentration, an example being Big John's Salvage.
The primus spawns at level 45+ and is seen with large groups of super mutants, most commonly at major super mutant outposts. They commonly wield super sledges or assault rifles, but may also be seen with missile launchers and, rarely, Fat Man launchers.
The warlord is the most powerful super mutant variant short of a Behemoth. Their extremely high Hit Point total means that they can withstand multiple head or limb shots from extremely powerful weapons like Gauss rifles without being crippled.
Behemoths are the most powerful super mutants by far, towering above any player character, at about 13 feet (4 m) tall. These super mutants are the oldest and strongest of their kind and are many times larger than any other humanoid creature, almost as large as a mirelurk queen. Unlike regular super mutants, they will not speak; instead, they will make monstrous roars. They are armed with a fire hydrant mounted on a large pipe. Other than that, they have the ability to throw heavy boulders at their enemies. Either way, both weapons are heavy hitters and will cause major damage against any enemy smaller than them. They carry a cage made from shopping carts on their back, similarly to their Vault 87 counterparts, which they use to carry boulders that they use during combat.
A behemoth can also be spawned by going to Med-Tek Research and heading north towards Greentop Nursery, where there will be a small vehicle crashed into a group of trees with a Jangles the Moon Monkey sitting inside, which will trigger a behemoth spawn point nearby when picked up.
There is a chance a standard behemoth will spawn around the outskirts of the remains of the institute after beating the game with the Brotherhood of Steel ending.
In the Nuka-World add-on, a behemoth can be found in the north section of the map, in a small lake near Dry Rock Gulch.
Multiple behemoths may partake in an assault on The Castle during the repeatable Defend the Castle quest if super mutants comprise the randomly chosen enemy and the player character is at a very high level. There is usually only one behemoth in each wave, but it is possible for two or more to spawn simultaneously.
Behemoths in Fallout 4 can respawn, unlike Fallout 3, where they were unique encounters. The player character can find a unique behemoth named Swan at Swan's Pond, and another unique behemoth in the Far Harbor add-on named Grun at the Vim! Pop factory.
Glowing behemoths are highly irradiated and can damage enemies with radiation when nearby. Unlike other glowing enemies, this variant appears identical to regular behemoths. Their existence seemingly contradicts super mutants’ established immunity to radiation.
Epic behemoths are an immensely powerful variation of average super mutant behemoths, and, to some extent, are more clever in combat. They tend to appear in forest areas, which they may use to their advantage by hiding behind trees. They also will block their face with their hand quite often, especially when fighting at melee range, allowing for a chance to get in several hits. They are more upright than many standard behemoths in appearance, and although they are quicker, they use similar fighting techniques, such as smashing, knocking the player character down and hurling boulders. Aside from being able to sustain more damage, they can be crippled if low on health and will slump to the ground on their side, where they can be finished off.