Don´t get me wrong, I loved the series. But after seeing how much lore it meddles with got me thinking that there had to have been ways around this. So I've drawn up some alternatives that I may not have backed with enough of the pre-existing lore. I´ll try to make it as lore friendly as I can. Let´s get started.
First, I´d find an entirely different setting than California, but it´d still be close to Nevada so Hank wouldn't have to trek too far to reach New Vegas. I´d pick a place closer to the commonwealth or the capital wasteland, but we all know we want to see the mojave wasteland in live action. Also, it´d scrap the need for an explanation on why the Master didn´t bother with Vaults 31, 32, 33, and 4. In the reimagining, the Fallout Tv series would be taking place in the north part of Wyoming. That way, more ambiguity is left over whether the great khans or the white legs would ever settle down there. Additionally, the Prydwen will not make a cameo so as to leave more ambiguity over the fate of the commonwealth conflict.
Then comes the characters. Since Shady Sands is not destroyed, Maximus´ background will be different. He will still be an NCR citizen, just not one that lived in Shady Sands. Instead, he’ll be the son of a brahmin baron in Wyoming. But he’d be forced to leave when the Legion tore through his town, and he’d be hunted down by legionary recruits. Those recruits would be shot dead by Brotherhood paladins. Thus, cementing a long-term hatred for the NCR for a lack of protection.
The Ghoul would be in the early stages of turning feral, and there would be scenes that highlight this change. I don’t have much else planned for him, but we can agree that an anti-feral drug is kinda stupid.
In favor of breaking the tradition of family members leaving the vault to search for each other, Lucy and Hank will not be related. However, Norm will still be related to Hank. This is done so that there is a rivalry between Norm and Lucy to be considered for a future position as overseer. Lucy will try harder given that she’s not the daughter of Hank, and Norm will hardly try given his father’s status. That means when Lucy leaves the vault, she does so to prove herself to her fellow dwellers. And when Moldaver reveals Hank’s secrets, Lucy will be crushed by the fact that the man that inspired her conspired to bring about the apocalypse. Additionally, Norm would want to follow Lucy, but Rose (she’s alive in this reimagining) will keep him in the vault for fear of losing him to the wasteland as well.
Wilzig, instead of being an Enclave scientist would be a scribe for the West-coast Brotherhood who despises their hoarding of technology instead of using it to benefit others. So cold fusion is instead crafted in a BOS bunker, making Wilzig´s and Dogmeat´s eventual escape more complicated. Wilzig could make the laser turrets turn on the BOS members like in New Vegas. I make this change because it makes no sense for the Enclave to not send anyone after Wilzig despite their increased numbers and instead get the Brotherhood to do it. This way, the fight over cold fusion between the BOS and the NCR has more impact.
The company meeting that Barb and Bud hosted in the finale would be replaced by a meeting with what the Enclave was in pre-war times. The decision to nuke the world would make more sense given the Enclave’s beliefs and the resource wars. However, Mr. House would still get to make a cameo but it’d be a bit different. Frederick Sincliar wouldn’t get that botched cameo, it’s too inconsistent with who he was in the games. Anyways, in the reimagining, House would reach out to Cooper Howard and convince him to spy on his wife given her position with vault-tec. Once the wham line is pulled, he’ll hang up on Cooper and begin preparations for preserving Las Vegas.
Which leads us to New Vegas not being destroyed and the end credits not highlighting the devastation. Basically, I´m writing this because the lack of answers for the lore changes is screwing me big time. Maybe John Nolan and Bethesda have good reasons for these canon changes, maybe they don´t. And maybe this reimagining would appeal more to veteran fallout fans instead of newcomers, which could´ve limited it´s success. That´s my two cents.