Im calling it now. The enclave will be in it, the BOS, the master will be retconned and have some confusing ass lore. The NCR will be retconned to an almost unrecognizable state. Pointless race pallete swaps of pre-existing characters like a Black Tandi, or a Asian Mr House. There will be some controversy with the actors and actresses running their mouths on social media attacking fans right before and after the premiere (that's a Netflix rule). It will be extremely different than the games. Think Fallout BOS or that god awful Halo show where theres a fucking Toyata SUV in the background or the resident evil show with a black Albert wesker and the whole show is basically a really bad teenage girl drama.
One of the directors or producers will be found out that he's a sex pest (roughly 25 percent of the time this happens with Netflix adaptations). And the story will probably revolve yet again around finding someone, or something. There will be behind the scenes drama. There's also a 50 percent chance it'll be fucking preachy and include IRL politics. Like vault security not liking black Vault Dwellers, even though discrimination based on race doesn't exist in the fallout world. It's 2023, everything has to make a statement about IRL politics even though most of the time it doesn't fit the setting.
In the off chance it's good. It'll be cancelled after the first season, as per Netflixes unofficial rule where anything good must be stopped, and something godawful can get 8+ seasons.
I've seen so much garbage from Netflix, and the few things that are good get shit canned really fast, it makes it hard not to be extremely pessimistic. Their actions are so predictable at this point.