Seriously? At level 161? A play through gets real real boring after about level 38, but at level 161, to draw a big fat line emphasizing Dyre's point, you are going to have full pickpocket, sneak, Ninja and Blitz.
So presuming you have deliberately challenged yourself by dumping any drug/ possessions you would typically have at this level, the most trivial is reverse pickpocketing grenades which are plentiful in Mass fusion, but if none are present, they have no defensive armor advantage because you have pickpocketed all of it- which at Level 161 should have respawned at Heavy not Sturdy but nevermind such nitpick points. Stealing the fusion core will dismount the commander from his PA if you don't shoot it out as suggested. Anywho, melee-stealth style combat is maybe the second simplest approach and given that you are going to be able to find or pickpocket at least one melee weapon in all of mass fusion, it is trivial to take this assortment of opponents by being patient working from their perimeter in and picking off each one using sneak/ninja/blitz to take individuals then ducking and hiding until you are back in hidden mode for the next blitz.