Give me some of your best pitches for a new setting in the Fallout universe,
Personally, and I may be biased since I grew up there, but I think Baltimore would be a good one. It sits right on the Mason-Dixon line, so you get a nice mix of northern/southern influence. There's a a lot of history there (the Star-Spangled Banner was written during the Battle of Baltimore). It's a huge city with a diversity of environments, from sprawling countryside, to suburbs, the inner city, the harbor, industrial parks, forests, swamps, etc. Maybe even have a cameo by John Waters. And it's near DC, so player can revisit some of the places from Fallout 3 for a bit of nostalgia. You can also play into the local camp and idiocentricities (NukaBohemian, Huns/Hons raiders, Druid Hill filled with actual Druids).
Honorable mentions: St. Louis, New Orleans, Denver, Detroit
What do you think?