^ what they said

No freeside cause well its the NCR's toilet basically, Primm is near a prison, Novac is too close to a Legion camp, no Jaconstown cause of the muties, no roaming cause I dont want swarmed by Cazadors(btw thank Think Tank morons), so I pick Goodsprings

May as well be a wanderer like real life.

Jacobsttown would be quite safe. Far from Legion or raider camps, and has quite the defense system. Just avoid Keene, and you're good.